PMID- 22982413
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20121017
IS  - 1879-0038 (Electronic)
IS  - 0378-1119 (Linking)
VI  - 511
IP  - 1
DP  - 2012 Dec 10
TI  - The role of chemokine and chemokine receptor gene variants on the susceptibility 
      and clinicopathological characteristics of bladder cancer.
PG  - 7-11
LID - S0378-1119(12)01092-X [pii]
LID - 10.1016/j.gene.2012.09.011 [doi]
AB  - The gene variants of the chemokine and chemokine receptor genes associated with 
      inflammation may be involved in cancer initiation and progression. The aim of 
      this study was to explore the possible association of monocyte chemoattractant 
      protein-1 (MCP-1) A2518G, stromal cell derived factor 1 (SDF-1) 3'A and chemokine 
      receptors CCR2A V64I, CCR5 Delta32, CCR5 59029 and CXCR4 gene polymorphisms with the 
      risk and clinicopathological characteristics of bladder cancer (BC) in a Turkish 
      population. The genotyping was done by PCR and PCR-Restriction Fragment Length 
      Polymorphism (RFLP) methods in 142 histologically confirmed BC patients and 197 
      controls. The SDF-1 3'AA genotype conferred significantly increased 
      susceptibility to BC. The carriers with AA genotype or at least one A allele of 
      CCR2 had an increased risk of developing BC. CCR5 wt/Delta32 genotype and CCR5 Delta32 
      allele were also observed to be involved in the susceptibility to BC. 
      Additionally, the combination of CCR2 V64I and CCR5 Delta32 (i.e., GG-wt/Delta32) was 
      found to be associated with BC risk. With respect to the stage of BC, the AA 
      genotype of SDF-1 and at least one T allele of CXCR4 were significantly 
      associated with high T stage as compared to GG genotype of SDF-1 and CC genotype 
      of CXCR4. Furthermore, BC patients with AA genotype or at least one A allele of 
      CCR2 had an increased risk of high grade and stage tumors as compared to those 
      with GG genotype. Our results suggest that the genetic variants of SDF-1 3'A, 
      CCR2A V64I and CCR5 Delta32 gene polymorphisms may modify the BC risk. Furthermore, 
      SDF-1 3'A, CCR2A V64I and CXCR4 gene polymorphisms may contribute to the muscle 
      invasive BC in a Turkish population.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Kucukgergin, Canan
AU  - Kucukgergin C
AD  - Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, 
      Istanbul, 34093, Turkey.
FAU - Isman, Ferruh K
AU  - Isman FK
FAU - Dasdemir, Selcuk
AU  - Dasdemir S
FAU - Cakmakoglu, Bedia
AU  - Cakmakoglu B
FAU - Sanli, Oner
AU  - Sanli O
FAU - Gokkusu, Cahide
AU  - Gokkusu C
FAU - Seckin, Sule
AU  - Seckin S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120914
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (CCL2 protein, human)
RN  - 0 (CCR2 protein, human)
RN  - 0 (CXCL12 protein, human)
RN  - 0 (CXCR4 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CXCL12)
RN  - 0 (Chemokines)
RN  - 0 (DNA Primers)
RN  - 0 (Receptors, CCR2)
RN  - 0 (Receptors, CCR5)
RN  - 0 (Receptors, CXCR4)
RN  - 0 (Receptors, Chemokine)
SB  - IM
MH  - Aged
MH  - Base Sequence
MH  - Case-Control Studies
MH  - Chemokine CCL2/genetics
MH  - Chemokine CXCL12/genetics
MH  - Chemokines/*genetics
MH  - DNA Primers/genetics
MH  - Epistasis, Genetic
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - *Genetic Variation
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Receptors, CCR2/genetics
MH  - Receptors, CCR5/genetics
MH  - Receptors, CXCR4/genetics
MH  - Receptors, Chemokine/*genetics
MH  - Risk Factors
MH  - Turkey
MH  - Urinary Bladder Neoplasms/*genetics/*immunology/pathology
EDAT- 2012/09/18 06:00
MHDA- 2013/01/11 06:00
CRDT- 2012/09/18 06:00
PHST- 2012/08/16 00:00 [received]
PHST- 2012/09/07 00:00 [accepted]
PHST- 2012/09/18 06:00 [entrez]
PHST- 2012/09/18 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
AID - S0378-1119(12)01092-X [pii]
AID - 10.1016/j.gene.2012.09.011 [doi]
PST - ppublish
SO  - Gene. 2012 Dec 10;511(1):7-11. doi: 10.1016/j.gene.2012.09.011. Epub 2012 Sep 14.