PMID- 22982671
OWN - NLM
STAT- MEDLINE
DCOM- 20130107
LR  - 20121105
IS  - 1090-2163 (Electronic)
IS  - 0008-8749 (Linking)
VI  - 278
IP  - 1-2
DP  - 2012 Jul-Aug
TI  - Adipose-derived stem cells induced dendritic cells undergo tolerance and inhibit 
      Th1 polarization.
PG  - 152-7
LID - S0008-8749(12)00157-8 [pii]
LID - 10.1016/j.cellimm.2012.07.008 [doi]
AB  - Adipose tissue-derived stem cells (ADSC) have been shown to possess stem cell 
      properties such as transdifferentiation, self-renewal and therapeutic potential. 
      However, the property of ADSC to accommodate immune system is still unknown. In 
      this study, ADSC were cocultured with allogenetic dendritic cells (DC), and then 
      treated DC were mixed with allogenetic CD4+ T cells. The results demonstrated 
      that ADSC could downregulate costimulatory molecules, including CD80, CD83, CD86, 
      and cytokine secretion such as interleukin (IL)-12 and tumor necrosis factor 
      (TNF)-alpha, while upregulate indoleamine-2,3-dioxygenase (IDO) of allogenetic DC. In 
      addition, treated DC could inhibit CD4+ T cell activation and naive T cells 
      toward Th1 polarization. The results suggest that ADSC could negatively modulate 
      immunity and induce immune tolerance, which provide a promising strategy in 
      transplantation or autoimmune disease.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Peng, Wei
AU  - Peng W
AD  - Department 4, Research Institute of Field Surgery, The 3rd Military Medical 
      University, State Key Lab of Trauma, Burns and Combined Injury, 400042 Chongqing, 
      China.
FAU - Gao, Tianjun
AU  - Gao T
FAU - Yang, Zai-Liang
AU  - Yang ZL
FAU - Zhang, Shi-Chang
AU  - Zhang SC
FAU - Ren, Ming-Liang
AU  - Ren ML
FAU - Wang, Zheng-Guo
AU  - Wang ZG
FAU - Zhang, Bo
AU  - Zhang B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120810
PL  - Netherlands
TA  - Cell Immunol
JT  - Cellular immunology
JID - 1246405
RN  - 0 (Antigens, CD)
RN  - 0 (Indoleamine-Pyrrole 2,3,-Dioxygenase)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 187348-17-0 (Interleukin-12)
SB  - IM
MH  - Adipose Tissue/cytology/*immunology/metabolism
MH  - Adult
MH  - Antigens, CD/genetics/immunology
MH  - CD4-Positive T-Lymphocytes/cytology/immunology/metabolism
MH  - Cell Communication/genetics/*immunology
MH  - Cell Differentiation/immunology
MH  - Coculture Techniques
MH  - Dendritic Cells/cytology/*immunology/metabolism
MH  - Gene Expression Regulation
MH  - Humans
MH  - *Immune Tolerance
MH  - Indoleamine-Pyrrole 2,3,-Dioxygenase/genetics/immunology
MH  - Interleukin-12/genetics/immunology
MH  - Middle Aged
MH  - Primary Cell Culture
MH  - Signal Transduction
MH  - Stem Cells/cytology/*immunology/metabolism
MH  - Tumor Necrosis Factor-alpha/genetics/immunology
EDAT- 2012/09/18 06:00
MHDA- 2013/01/08 06:00
CRDT- 2012/09/18 06:00
PHST- 2012/06/21 00:00 [received]
PHST- 2012/07/21 00:00 [revised]
PHST- 2012/07/23 00:00 [accepted]
PHST- 2012/09/18 06:00 [entrez]
PHST- 2012/09/18 06:00 [pubmed]
PHST- 2013/01/08 06:00 [medline]
AID - S0008-8749(12)00157-8 [pii]
AID - 10.1016/j.cellimm.2012.07.008 [doi]
PST - ppublish
SO  - Cell Immunol. 2012 Jul-Aug;278(1-2):152-7. doi: 10.1016/j.cellimm.2012.07.008. 
      Epub 2012 Aug 10.