PMID- 22983259
OWN - NLM
STAT- MEDLINE
DCOM- 20121218
LR  - 20161125
IS  - 1600-0455 (Electronic)
IS  - 0284-1851 (Linking)
VI  - 53
IP  - 8
DP  - 2012 Oct 1
TI  - An observational study to evaluate the efficiency and safety of ioversol 
      pre-filled syringes compared with ioversol bottles in contrast-enhanced 
      examinations.
PG  - 914-20
LID - 10.1258/ar.2012.120303 [doi]
AB  - BACKGROUND: The use of pre-filled syringes for contrast media (CM) administration 
      allows efficient and optimized workflow during radiologic diagnostic procedures, 
      and reduces the risk of contamination, providing benefits for both patients and 
      healthcare workers. PURPOSE: To compare the efficiency and safety of ioversol 
      (Optiray(TM)) bottles and pre-filled syringes in clinical practice. MATERIAL AND 
      METHODS: This was an observational, non-interventional, prospective, multicenter 
      study conducted at 72 centers in Germany. Patients undergoing contrast-enhanced 
      computed tomography (CT) examinations with ioversol were enrolled. The use of 
      ioversol bottles and pre-filled syringes in the diagnostic procedure was recorded 
      in terms of efficiency (residual volume, re-use of CM) and safety (adverse events 
      [AEs]). RESULTS: A total of 10,836 patients were enrolled and included in this 
      study. Ioversol bottles and syringes were used in 72% and 28% of cases, 
      respectively. Analysis of the volume of CM in bottles before and after 
      examinations, together with the volume used during the examination, suggested 
      that in 22.5% of cases a new bottle was connected during the procedure. Further 
      analysis revealed that in 80.2% of cases, the remaining volume of CM in the 
      bottles could potentially be used for subsequent investigations, compared with 
      <1% of cases for pre-filled syringes. For the total study population, AEs and 
      serious AEs were reported in 30 (0.28%) and four (0.037%) patients, respectively, 
      with no significant difference observed between ioversol bottles and syringes. 
      CONCLUSION: Administration of ioversol for contrast-enhanced CT examinations is 
      associated with a low incidence of AEs and is generally safe and well tolerated. 
      Ioversol pre-filled syringes were associated with lower residual volumes and less 
      potential re-use compared with bottles.
FAU - Vogl, Thomas J
AU  - Vogl TJ
AD  - Department of Diagnostic and Interventional Radiology, Johann Wolfgang Goethe 
      University Frankfurt, Germany. t.vogl@em.uni-frankfurt.de
FAU - Wessling, Johannes
AU  - Wessling J
FAU - Buerke, Boris
AU  - Buerke B
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20120914
PL  - England
TA  - Acta Radiol
JT  - Acta radiologica (Stockholm, Sweden : 1987)
JID - 8706123
RN  - 0 (Contrast Media)
RN  - 0 (Triiodobenzoic Acids)
RN  - N3RIB7X24K (ioversol)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Contrast Media/*administration & dosage
MH  - Equipment Reuse
MH  - Female
MH  - Humans
MH  - Injections, Intravenous/*instrumentation/*methods
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Radiographic Image Enhancement/methods
MH  - Syringes
MH  - Tomography, X-Ray Computed
MH  - Triiodobenzoic Acids/*administration & dosage
MH  - Young Adult
EDAT- 2012/09/18 06:00
MHDA- 2012/12/19 06:00
CRDT- 2012/09/18 06:00
PHST- 2012/09/18 06:00 [entrez]
PHST- 2012/09/18 06:00 [pubmed]
PHST- 2012/12/19 06:00 [medline]
AID - ar.2012.120303 [pii]
AID - 10.1258/ar.2012.120303 [doi]
PST - ppublish
SO  - Acta Radiol. 2012 Oct 1;53(8):914-20. doi: 10.1258/ar.2012.120303. Epub 2012 Sep 
      14.