PMID- 22984113
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20220331
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Linking)
VI  - 206
IP  - 11
DP  - 2012 Dec 1
TI  - High levels of immunoglobulin E autoantibody to 14-3-3 epsilon protein correlate 
      with protection against severe Plasmodium falciparum malaria.
PG  - 1781-9
LID - 10.1093/infdis/jis595 [doi]
AB  - Plasmodium falciparum infection generally induces elevated total plasma levels of 
      immunoglobulins, some of which recognize self- or parasite-specific antigens. To 
      our knowledge, we are the first to report high levels of functional 
      immunoglobulin E (IgE) autoantibodies recognizing brain 14-3-3 protein epsilon in 
      asymptomatic P. falciparum malaria. 14-3-3 epsilon protein belongs to a family of 
      proteins that binds to CD81, a member of the tetraspanin superfamily elicited in 
      hepatocyte invasion by sporozoites. Levels of expression of 14-3-3 epsilon protein were 
      found to be increased in vivo and in vitro during Plasmodium yoelii and P. 
      falciparum intrahepatic development. Collectively, these results indicate that 
      self-reactive IgE is produced during malaria. In addition, the negative 
      correlation between levels of self-reactive IgE to 14-3-3 epsilon protein and 
      parasitemia in asymptomatic malaria due to P. falciparum supports a role for 
      these IgE molecules in defense mechanisms, probably by interfering with 
      development of liver-stage parasites through the CD81 pathway.
FAU - Duarte, Joana
AU  - Duarte J
AD  - Instituto Gulbenkian de Ciencia, LEA CNRS-IGC, Oeiras, Portugal.
FAU - Herbert, Fabien
AU  - Herbert F
FAU - Guiyedi, Vincent
AU  - Guiyedi V
FAU - Franetich, Jean-Francois
AU  - Franetich JF
FAU - Roland, Jacques
AU  - Roland J
FAU - Cazenave, Pierre-Andre
AU  - Cazenave PA
FAU - Mazier, Dominique
AU  - Mazier D
FAU - Kombila, Maryvonne
AU  - Kombila M
FAU - Fesel, Constantin
AU  - Fesel C
FAU - Pied, Sylviane
AU  - Pied S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120914
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (14-3-3 Proteins)
RN  - 0 (Autoantibodies)
RN  - 0 (Autoantigens)
RN  - 0 (YWHAE protein, human)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - 14-3-3 Proteins/genetics/*immunology/metabolism
MH  - Animals
MH  - Anopheles/parasitology
MH  - Autoantibodies/*blood
MH  - Autoantigens
MH  - Child
MH  - Child, Preschool
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Gene Expression Regulation
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Infant
MH  - Liver/parasitology
MH  - Malaria, Falciparum/*immunology/pathology
MH  - Plasmodium falciparum/immunology/physiology
MH  - Plasmodium yoelii/immunology/physiology
EDAT- 2012/09/18 06:00
MHDA- 2013/01/11 06:00
CRDT- 2012/09/18 06:00
PHST- 2012/09/18 06:00 [entrez]
PHST- 2012/09/18 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
AID - jis595 [pii]
AID - 10.1093/infdis/jis595 [doi]
PST - ppublish
SO  - J Infect Dis. 2012 Dec 1;206(11):1781-9. doi: 10.1093/infdis/jis595. Epub 2012 
      Sep 14.