PMID- 22984471
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20220317
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 9
DP  - 2012
TI  - The association of cysteine with obesity, inflammatory cytokines and insulin 
      resistance in Hispanic children and adolescents.
PG  - e44166
LID - 10.1371/journal.pone.0044166 [doi]
LID - e44166
AB  - CONTEXT: Plasma total cysteine (tCys) independently relates to fat mass in 
      adults. Dietary cyst(e)ine promotes adiposity and decreases glucose tolerance in 
      some rodent models, but alleviates insulin resistance in others. OBJECTIVE: To 
      investigate whether the association of tCys with body fat extends to children at 
      particular risk of obesity, and whether tCys is associated with insulin 
      resistance and obesity-associated inflammation. METHODS: We explored the 
      cross-sectional relations of fasting plasma tCys and related metabolites with 
      body composition measured by dual-energy X-ray absorptiometry in 984 Hispanic 
      children and adolescents aged 4-19 years from the Viva La Familia Study. Linear 
      and logistic regression and dose-response curves were used to evaluate relations 
      of tCys with obesity, insulin resistance and inflammatory markers including 
      interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), monocyte 
      chemoattractant protein-1 (MCP-1) and C-reactive protein (CRP). RESULTS: tCys, 
      methionine and total homocysteine (tHcy) increased with age. Upper tCys quartile 
      was independently associated with a 5-fold increased risk of obesity (95% CI 
      3.5-8.0, P<0.001), and 2-fold risk of insulin resistance (95% CI: 1.6-5.0, 
      P<0.001; adjusted for body fat%). Within the overweight/obese subgroup, but not 
      in normal-weight children, tCys accounted for 9% of the variability in body fat% 
      (partial r = 0.30, P<0.001; adjusted for age and gender). tCys correlated 
      positively with serum non-esterified fatty acids and leptin, partly independent 
      of body fat, but was not associated with serum IL-6, TNF-alpha or MCP-1. A positive 
      correlation with CRP disappeared after adjustment for BMI. CONCLUSION: tCys is 
      independently associated with obesity and insulin resistance in Hispanic children 
      and adolescents, highlighting a previously underappreciated link between the 
      sulfur amino acid metabolic pathway and obesity and cardiometabolic risk.
FAU - Elshorbagy, Amany K
AU  - Elshorbagy AK
AD  - Department of Pharmacology, University of Oxford, Oxford, United Kingdom. 
      amany.elshorbagy@pharm.ox.ac.uk
FAU - Valdivia-Garcia, Maria
AU  - Valdivia-Garcia M
FAU - Refsum, Helga
AU  - Refsum H
FAU - Butte, Nancy
AU  - Butte N
LA  - eng
GR  - R01 DK059264/DK/NIDDK NIH HHS/United States
GR  - R01 DK080457/DK/NIDDK NIH HHS/United States
GR  - DK080457/DK/NIDDK NIH HHS/United States
GR  - DK59264/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20120911
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Adipokines)
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - K848JZ4886 (Cysteine)
SB  - IM
MH  - Adipokines/blood
MH  - Adipose Tissue/pathology
MH  - Adolescent
MH  - Anthropometry
MH  - Biomarkers/blood
MH  - Body Composition
MH  - Child
MH  - Cysteine/*blood
MH  - Cytokines/*blood
MH  - Female
MH  - *Hispanic or Latino
MH  - Humans
MH  - Inflammation Mediators/*blood
MH  - *Insulin Resistance
MH  - Male
MH  - Obesity/*blood/pathology
MH  - Odds Ratio
MH  - Overweight/blood/pathology
MH  - Young Adult
PMC - PMC3439485
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2012/09/18 06:00
MHDA- 2013/03/13 06:00
PMCR- 2012/09/11
CRDT- 2012/09/18 06:00
PHST- 2012/05/10 00:00 [received]
PHST- 2012/07/30 00:00 [accepted]
PHST- 2012/09/18 06:00 [entrez]
PHST- 2012/09/18 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
PHST- 2012/09/11 00:00 [pmc-release]
AID - PONE-D-12-13489 [pii]
AID - 10.1371/journal.pone.0044166 [doi]
PST - ppublish
SO  - PLoS One. 2012;7(9):e44166. doi: 10.1371/journal.pone.0044166. Epub 2012 Sep 11.