PMID- 22984665
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120918
LR  - 20211021
IS  - 2234-3164 (Electronic)
IS  - 2234-1900 (Print)
IS  - 2234-1900 (Linking)
VI  - 29
IP  - 3
DP  - 2011 Sep
TI  - Radiation-induced brain injury: retrospective analysis of twelve pathologically 
      proven cases.
PG  - 147-55
LID - 10.3857/roj.2011.29.3.147 [doi]
AB  - PURPOSE: This study was designed to determine the influencing factors and 
      clinical course of pathologically proven cases of radiation-induced brain injury 
      (RIBI). MATERIALS AND METHODS: The pathologic records of twelve patients were 
      reviewed; these patients underwent surgery following radiotherapy due to disease 
      progression found by follow-up imaging. However, they were finally diagnosed with 
      RIBI. All patients had been treated with 3-dimensional conventional fractionated 
      radiotherapy and/or radiosurgery for primary or metastatic brain tumors with or 
      without chemotherapy. The histological distribution was as follows: two falx 
      meningioma, six glioblastoma multiform (GBM), two anaplastic oligodendroglioma, 
      one low grade oligodendroglioma, and one small cell lung cancer with brain 
      metastasis. RESULTS: Radiation necrosis was noted in eight patients and the 
      remaining four were diagnosed with radiation change. Gender (p = 0.061) and 
      biologically equivalent dose (BED)(3) (p = 0.084) were the only marginally 
      influencing factors of radiation necrosis. Median time to RIBI was 7.3 months 
      (range, 0.5 to 61 months). Three prolonged survivors with GBM were observed. In 
      the subgroup analysis of high grade gliomas, RIBI that developed <6 months after 
      radiotherapy was associated with inferior overall survival rates compared to 
      cases of RIBI that occurred >/=6 months (p = 0.085). CONCLUSION: Our study 
      demonstrated that RIBI could occur in early periods after conventional 
      fractionated brain radiotherapy within normal tolerable dose ranges. Studies with 
      a larger number of patients are required to identify the strong influencing 
      factors for RIBI development.
FAU - Lee, Dong-Soo
AU  - Lee DS
AD  - Department of Radiation Oncology, The Cancer Center of Seoul St. Mary's Hospital, 
      The Catholic University of Korea, Seoul, Korea.
FAU - Yu, Mina
AU  - Yu M
FAU - Jang, Hong-Seok
AU  - Jang HS
FAU - Kim, Yeon-Sil
AU  - Kim YS
FAU - Choi, Byung-Ock
AU  - Choi BO
FAU - Kang, Young-Nam
AU  - Kang YN
FAU - Lee, Youn-Soo
AU  - Lee YS
FAU - Kim, Dong-Chul
AU  - Kim DC
FAU - Hong, Yong-Kil
AU  - Hong YK
FAU - Jeun, Sin-Soo
AU  - Jeun SS
FAU - Yoon, Sei-Chul
AU  - Yoon SC
LA  - eng
PT  - Journal Article
DEP - 20110930
PL  - Korea (South)
TA  - Radiat Oncol J
JT  - Radiation oncology journal
JID - 101577577
PMC - PMC3429897
OTO - NOTNLM
OT  - Brain tumor
OT  - Chemoradiation
OT  - Radiation injury
OT  - Radiation necrosis
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2012/09/18 06:00
MHDA- 2012/09/18 06:01
PMCR- 2011/09/01
CRDT- 2012/09/18 06:00
PHST- 2011/03/24 00:00 [received]
PHST- 2011/06/08 00:00 [revised]
PHST- 2011/06/15 00:00 [accepted]
PHST- 2012/09/18 06:00 [entrez]
PHST- 2012/09/18 06:00 [pubmed]
PHST- 2012/09/18 06:01 [medline]
PHST- 2011/09/01 00:00 [pmc-release]
AID - 10.3857/roj.2011.29.3.147 [doi]
PST - ppublish
SO  - Radiat Oncol J. 2011 Sep;29(3):147-55. doi: 10.3857/roj.2011.29.3.147. Epub 2011 
      Sep 30.