PMID- 22985088
OWN - NLM
STAT- MEDLINE
DCOM- 20130225
LR  - 20200930
IS  - 1530-6992 (Electronic)
IS  - 1530-6984 (Linking)
VI  - 12
IP  - 10
DP  - 2012 Oct 10
TI  - Enhanced sensing of nucleic acids with silicon nanowire field effect transistor 
      biosensors.
PG  - 5262-8
LID - 10.1021/nl302476h [doi]
AB  - Silicon nanowire (SiNW) field effect transistors (FETs) have emerged as powerful 
      sensors for ultrasensitive, direct electrical readout, and label-free 
      biological/chemical detection. The sensing mechanism of SiNW-FET can be 
      understood in terms of the change in charge density at the SiNW surface after 
      hybridization. So far, there have been limited systematic studies on fundamental 
      factors related to device sensitivity to further make clear the overall effect on 
      sensing sensitivity. Here, we present an analytical result for our triangle 
      cross-section wire for predicting the sensitivity of nanowire surface-charge 
      sensors. It was confirmed through sensing experiments that the back-gated 
      SiNW-FET sensor had the highest percentage current response in the subthreshold 
      regime and the sensor performance could be optimized in low buffer ionic strength 
      and at moderate probe concentration. The optimized SiNW-FET nanosensor revealed 
      ultrahigh sensitivity for rapid and reliable detection of target DNA with a 
      detection limit of 0.1 fM and high specificity for single-nucleotide polymorphism 
      discrimination. In our work, enhanced sensing of biological species by 
      optimization of operating parameters and fundamental understanding for SiNW FET 
      detection limit was obtained.
FAU - Gao, Anran
AU  - Gao A
AD  - State Key Laboratories of Transducer Technology and Science and Technology on 
      Micro-system Laboratory, Shanghai Institute of Microsystem and Information 
      Technology, Chinese Academy of Sciences, Shanghai 200050, China.
FAU - Lu, Na
AU  - Lu N
FAU - Wang, Yuchen
AU  - Wang Y
FAU - Dai, Pengfei
AU  - Dai P
FAU - Li, Tie
AU  - Li T
FAU - Gao, Xiuli
AU  - Gao X
FAU - Wang, Yuelin
AU  - Wang Y
FAU - Fan, Chunhai
AU  - Fan C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120920
PL  - United States
TA  - Nano Lett
JT  - Nano letters
JID - 101088070
RN  - 0 (DNA Probes)
RN  - 0 (Nucleic Acids)
RN  - Z4152N8IUI (Silicon)
SB  - IM
MH  - Biosensing Techniques/*instrumentation
MH  - DNA Probes/chemistry/genetics
MH  - Nanotechnology
MH  - *Nanowires
MH  - Nucleic Acid Hybridization
MH  - Nucleic Acids/*analysis
MH  - Osmolar Concentration
MH  - Silicon
MH  - Static Electricity
MH  - *Transistors, Electronic
EDAT- 2012/09/19 06:00
MHDA- 2013/02/26 06:00
CRDT- 2012/09/19 06:00
PHST- 2012/09/19 06:00 [entrez]
PHST- 2012/09/19 06:00 [pubmed]
PHST- 2013/02/26 06:00 [medline]
AID - 10.1021/nl302476h [doi]
PST - ppublish
SO  - Nano Lett. 2012 Oct 10;12(10):5262-8. doi: 10.1021/nl302476h. Epub 2012 Sep 20.