PMID- 22985518
OWN - NLM
STAT- MEDLINE
DCOM- 20121220
LR  - 20211203
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 528
IP  - 2
DP  - 2012 Oct 24
TI  - Heptamethoxyflavone, a citrus flavonoid, enhances brain-derived neurotrophic 
      factor production and neurogenesis in the hippocampus following cerebral global 
      ischemia in mice.
PG  - 190-5
LID - S0304-3940(12)01173-1 [pii]
LID - 10.1016/j.neulet.2012.08.079 [doi]
AB  - In the present study using a transient global ischemia mouse model, we showed 
      that (1) a citrus flavonoid 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF) induced the 
      phosphorylation of extracellular signal-regulated kinases 1/2 (ERK1/2) and cAMP 
      response element-binding protein (CREB) in the hippocampus after ischemia; (2) 
      HMF increased the expression of brain-derived neurotrophic factor (BDNF), a 
      representative neurotrophic factor in the central nervous system, in the 
      hippocampal dentate gyrus, and most BDNF-positive cells were also stained with 
      anti-glial fibrillary acidic protein (one of the major intermediate filament 
      proteins of mature astrocytes) and (3) HMF increased doublecortin positive 
      neuronal precursor cells in the dentate gyrus subventricular zone or subgranular 
      zone. These results suggest that HMF has the ability to induce BDNF production in 
      astrocytes and enhance neurogenesis after brain ischemia, which may be mediated 
      by activation of ERK1/2 and CREB.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Okuyama, Satoshi
AU  - Okuyama S
AD  - Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, 
      Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan. 
      sokuyama@cc.matsuyama-u.ac.jp
FAU - Shimada, Naoko
AU  - Shimada N
FAU - Kaji, Miki
AU  - Kaji M
FAU - Morita, Mayu
AU  - Morita M
FAU - Miyoshi, Kazuhiro
AU  - Miyoshi K
FAU - Minami, Sona
AU  - Minami S
FAU - Amakura, Yoshiaki
AU  - Amakura Y
FAU - Yoshimura, Morio
AU  - Yoshimura M
FAU - Yoshida, Takashi
AU  - Yoshida T
FAU - Watanabe, Sono
AU  - Watanabe S
FAU - Nakajima, Mitsunari
AU  - Nakajima M
FAU - Furukawa, Yoshiko
AU  - Furukawa Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120907
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Creb1 protein, mouse)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Doublecortin Domain Proteins)
RN  - 0 (Flavonoids)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Neuropeptides)
RN  - 1178-24-1 (3,3',4',5,6,7,8-heptamethoxyflavone)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
SB  - IM
MH  - Animals
MH  - Astrocytes/metabolism/pathology
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis
MH  - Cyclic AMP Response Element-Binding Protein/metabolism
MH  - Doublecortin Domain Proteins
MH  - Flavonoids/*pharmacology
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Hippocampus/*drug effects/metabolism/pathology
MH  - Ischemic Attack, Transient/*metabolism/pathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Microtubule-Associated Proteins/metabolism
MH  - Mitogen-Activated Protein Kinase 1/metabolism
MH  - Mitogen-Activated Protein Kinase 3/metabolism
MH  - Neural Stem Cells/metabolism/pathology
MH  - Neurogenesis/drug effects
MH  - Neurons/metabolism/pathology
MH  - Neuropeptides/metabolism
MH  - Phosphorylation
EDAT- 2012/09/19 06:00
MHDA- 2012/12/21 06:00
CRDT- 2012/09/19 06:00
PHST- 2012/07/02 00:00 [received]
PHST- 2012/08/22 00:00 [revised]
PHST- 2012/08/23 00:00 [accepted]
PHST- 2012/09/19 06:00 [entrez]
PHST- 2012/09/19 06:00 [pubmed]
PHST- 2012/12/21 06:00 [medline]
AID - S0304-3940(12)01173-1 [pii]
AID - 10.1016/j.neulet.2012.08.079 [doi]
PST - ppublish
SO  - Neurosci Lett. 2012 Oct 24;528(2):190-5. doi: 10.1016/j.neulet.2012.08.079. Epub 
      2012 Sep 7.