PMID- 22985552
OWN - NLM
STAT- MEDLINE
DCOM- 20130725
LR  - 20120918
IS  - 1673-4254 (Print)
IS  - 1673-4254 (Linking)
VI  - 32
IP  - 9
DP  - 2012 Sep
TI  - [Effect of maternal staphylococcal enterotoxin B administration during pregnancy 
      on CD3(+) TCR Vbeta8(+)T cells of adult offspring rats].
PG  - 1230-3
AB  - OBJECTIVE: To investigate the influence of maternal staphylococcal enterotoxin B 
      (SEB) administration during pregnancy on CD3(+) TCR Vbeta8(+)T cells of adult offspring 
      rats. METHODS: Pregnant maternal rats at gestational day (GD) 16 were injected 
      intravenously with 15 microg SEB in 0.2 ml PBS (SEB group), and the control rats 
      receive the same volume of PBS. Flow cytometry was used to determine the levels 
      of CD3(+) TCR Vbeta8(+)T cells in both the thymus and peripheral blood of adult 
      offspring rats and the response of these cells to a secondary SEB administration. 
      RESULTS: Maternal SEB administration during pregnancy significantly decreased the 
      percentages of CD3(+)TCR Vbeta8(+)T cells in the thymus in adult female (1.760-2.714) 
      and male (1.098-2.088) offspring rats (P<0.05). The change of CD3(+)TCR Vbeta8(+)T cells 
      in the peripheral blood was similar to that in the thymus. In the control adult 
      offspring rats, SEB administration at adulthood significantly reduced the 
      percentages of CD3(+)TCR Vbeta8(+)T cells in both the thymus and peripheral blood 
      (P<0.05). But in SEB group, a secondary SEB administration in adult offspring 
      rats significantly increased the percentage of CD3(+)TCR Vbeta8(+)T cells in the 
      peripheral blood (P<0.05) but not in the thymus (P>0.05). CONCLUSION: Maternal 
      SEB administration during pregnancy can change the response of CD3(+) TCR Vbeta8(+)T 
      cells of adult offspring rats to a secondary SEB administration.
FAU - Guan, Junchang
AU  - Guan J
AD  - Department of Microbiology and Parasitology, Bengbu Medical College, Bengbu 
      233030, China. gic-2003@sohu.com
FAU - Liu, Yong
AU  - Liu Y
FAU - Kong, Xiaoming
AU  - Kong X
FAU - Zhu, Xiang
AU  - Zhu X
FAU - Yu, Fengling
AU  - Yu F
FAU - Lin, Na
AU  - Lin N
FAU - Liu, Congsen
AU  - Liu C
FAU - Zhang, Tao
AU  - Zhang T
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Nan Fang Yi Ke Da Xue Xue Bao
JT  - Nan fang yi ke da xue xue bao = Journal of Southern Medical University
JID - 101266132
RN  - 0 (Enterotoxins)
RN  - 39424-53-8 (enterotoxin B, staphylococcal)
SB  - IM
MH  - Animals
MH  - Enterotoxins/*adverse effects
MH  - Female
MH  - Male
MH  - Maternal Exposure/*adverse effects
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - T-Lymphocyte Subsets/*drug effects
EDAT- 2012/09/19 06:00
MHDA- 2013/07/26 06:00
CRDT- 2012/09/19 06:00
PHST- 2012/09/19 06:00 [entrez]
PHST- 2012/09/19 06:00 [pubmed]
PHST- 2013/07/26 06:00 [medline]
PST - ppublish
SO  - Nan Fang Yi Ke Da Xue Xue Bao. 2012 Sep;32(9):1230-3.