PMID- 22986270
OWN - NLM
STAT- MEDLINE
DCOM- 20130923
LR  - 20190606
IS  - 1347-7439 (Electronic)
IS  - 0916-7250 (Linking)
VI  - 75
IP  - 2
DP  - 2013 Feb
TI  - Monocyte chemoattractant protein-1 in dogs affected with neoplasia or 
      inflammation.
PG  - 173-7
AB  - Monocyte chemoattractant protein-1 (MCP-1) is a member of the C-C family 
      chemokines, which mobilizes monocytes from bone marrow to the site of 
      inflammation. To evaluate the clinical utility of canine MCP-1 as a blood test 
      item, we measured serum MCP-1 concentrations in normal and ill dogs. Reference 
      interval of canine MCP-1 was established as 115.6-176.9 pg/ml. Serum MCP-1 
      concentrations increased in the dogs affected with neoplastic (518.0 +/- 84.8 
      pg/ml), inflammatory (257.0 +/- 42.5 pg/ml) or other diseases (360.3 +/- 45.2 pg/ml). 
      The results showed high sensitivity of MCP-1 to detect neoplasia and 
      inflammation. Moreover, MCP-1 increased in some cases in which C-reactive protein 
      didn't increase. MCP-1 might be helpful as a screening blood test marker for 
      detection of neoplasia and inflammation in dogs.
FAU - Ishioka, Katsumi
AU  - Ishioka K
AD  - Department of Veterinary Nursing, School of Veterinary Nursing and Technology, 
      Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 
      Tokyo, Japan. katsumi@nvlu.ac.jp
FAU - Suzuki, Yumi
AU  - Suzuki Y
FAU - Tajima, Kana
AU  - Tajima K
FAU - Ohtaki, Sumire
AU  - Ohtaki S
FAU - Miyabe, Masahiro
AU  - Miyabe M
FAU - Takasaki, Mariko
AU  - Takasaki M
FAU - Mori, Akihiro
AU  - Mori A
FAU - Momota, Yutaka
AU  - Momota Y
FAU - Azakami, Daigo
AU  - Azakami D
FAU - Sako, Toshinori
AU  - Sako T
LA  - eng
PT  - Journal Article
DEP - 20120914
PL  - Japan
TA  - J Vet Med Sci
JT  - The Journal of veterinary medical science
JID - 9105360
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Animals
MH  - Biomarkers
MH  - Chemokine CCL2/genetics/*metabolism
MH  - Dog Diseases/*metabolism
MH  - Dogs
MH  - Female
MH  - Gene Expression Regulation/physiology
MH  - Inflammation/metabolism/*veterinary
MH  - Male
MH  - Neoplasms/*metabolism
EDAT- 2012/09/19 06:00
MHDA- 2013/09/24 06:00
CRDT- 2012/09/19 06:00
PHST- 2012/09/19 06:00 [entrez]
PHST- 2012/09/19 06:00 [pubmed]
PHST- 2013/09/24 06:00 [medline]
AID - DN/JST.JSTAGE/jvms/12-0169 [pii]
AID - 10.1292/jvms.12-0169 [doi]
PST - ppublish
SO  - J Vet Med Sci. 2013 Feb;75(2):173-7. doi: 10.1292/jvms.12-0169. Epub 2012 Sep 14.