PMID- 22986365
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20190911
IS  - 1347-8648 (Electronic)
IS  - 1347-8613 (Linking)
VI  - 120
IP  - 2
DP  - 2012
TI  - Discriminative stimulus effects of hallucinogenic drugs: a possible relation to 
      reinforcing and aversive effects.
PG  - 70-6
AB  - The subjective effects of drugs are related to the kinds of feelings they 
      produce, such as euphoria or dysphoria. One of the methods that can be used to 
      study these effects is the drug discrimination procedure. Many researchers are 
      trying to elucidate the mechanisms that underlie the discriminative stimulus 
      effects of abused drugs (e.g., alcohol, psychostimulants, and opioids). Over the 
      past two decades, the patterns of drug abuse have changed, so that 
      club/recreational drugs such as phencyclidine (PCP), 
      3,4-methylenedioxymethamphetamine (MDMA), lysergic acid diethylamide (LSD), and 
      ketamine, which induce perceptual distortions, like hallucinations, are now more 
      commonly abused, especially in younger generations. However, the mechanisms of 
      the discriminative stimulus effects of hallucinogenic drugs are not yet fully 
      clear. This review will briefly focus on the recent findings regarding 
      hallucinogenic/psychotomimetic drug-induced discriminative stimulus effects in 
      animals. In summary, recent research has demonstrated that there are at least two 
      plausible mechanisms that can explain the cue of the discriminative stimulus 
      effects of hallucinogenic drugs; one is mediated mainly by 5-HT(2) receptors, and 
      the other is mediated through sigma-1 (sigma(1))-receptor chaperone regulated by 
      endogenous hallucinogenic ligand.
FAU - Mori, Tomohisa
AU  - Mori T
AD  - Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical 
      Sciences, Tokyo, Japan.
FAU - Yoshizawa, Kazumi
AU  - Yoshizawa K
FAU - Shibasaki, Masahiro
AU  - Shibasaki M
FAU - Suzuki, Tsutomu
AU  - Suzuki T
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120915
PL  - Japan
TA  - J Pharmacol Sci
JT  - Journal of pharmacological sciences
JID - 101167001
RN  - 0 (Cannabinoids)
RN  - 0 (Hallucinogens)
RN  - 0 (Receptors, Opioid, kappa)
RN  - 0 (Receptors, sigma)
RN  - 333DO1RDJY (Serotonin)
SB  - IM
MH  - Animals
MH  - *Avoidance Learning
MH  - Cannabinoids/pharmacology
MH  - Hallucinogens/*pharmacology
MH  - Receptors, Opioid, kappa/agonists
MH  - Receptors, sigma/drug effects
MH  - Serotonin/pharmacology
EDAT- 2012/09/19 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/09/19 06:00
PHST- 2012/09/19 06:00 [entrez]
PHST- 2012/09/19 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - DN/JST.JSTAGE/jphs/12R08CP [pii]
AID - 10.1254/jphs.12r08cp [doi]
PST - ppublish
SO  - J Pharmacol Sci. 2012;120(2):70-6. doi: 10.1254/jphs.12r08cp. Epub 2012 Sep 15.