PMID- 22986456
OWN - NLM
STAT- MEDLINE
DCOM- 20130722
LR  - 20221207
IS  - 1348-4540 (Electronic)
IS  - 0918-8959 (Linking)
VI  - 60
IP  - 1
DP  - 2013
TI  - Decreased serum chemerin levels in male Japanese patients with type 2 diabetes: 
      sex dimorphism.
PG  - 37-44
AB  - Chemerin, a recently discovered adipocytokine plays an important role in obesity 
      and obesity-associated metabolic complications. However, the role of chemerin in 
      the pathogenesis of type 2 diabetes mellitus (T2DM) has not fully been 
      elucidated. We compared the serum chemerin levels and metabolic parameters 
      between 88 control subjects, 86 patients with metabolic syndrome (MS), and 147 
      patients with T2DM in a Japanese population and further analyzed their 
      correlation. Enzyme-linked immunosorbent assay was used to measure the serum 
      chemerin levels. The chemerin levels were significantly higher in male than in 
      female control subjects (p < 0.005), with significant decreases in patients with 
      T2DM compared with those with MS and control subjects (164.9 +/- 6.3 ng/mL vs. 
      209.8 +/- 7.7 and 218.7 +/- 7.3 ng/mL; p < 0.0001 vs. p < 0.0001, respectively) but 
      no significant differences in female subjects. The multiple regression analysis 
      revealed that the chemerin levels negatively correlated with the fasting glucose 
      and HbA1c levels in total and male subjects. In the patients with T2DM, the 
      chemerin levels negatively correlated with fasting glucose and high-density 
      lipoprotein cholesterol but positively correlated with body mass index (BMI), and 
      total cholesterol and triglyceride levels. The negative correlation between the 
      chemerin and fasting glucose levels remained significant after adjustment for 
      age, sex, and BMI in the total and male subjects and those with T2DM. These 
      results suggest the role of chemerin in sex dimorphism and a potential link 
      between chemerin levels and T2DM pathogenesis in a Japanese population.
FAU - Takahashi, Michiko
AU  - Takahashi M
AD  - Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, Kobe 650-0017, Japan.
FAU - Inomata, Sumie
AU  - Inomata S
FAU - Okimura, Yasuhiko
AU  - Okimura Y
FAU - Iguchi, Genzo
AU  - Iguchi G
FAU - Fukuoka, Hidenori
AU  - Fukuoka H
FAU - Miyake, Kazuaki
AU  - Miyake K
FAU - Koga, Daisuke
AU  - Koga D
FAU - Akamatsu, Suguru
AU  - Akamatsu S
FAU - Kasuga, Masato
AU  - Kasuga M
FAU - Takahashi, Yutaka
AU  - Takahashi Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121013
PL  - Japan
TA  - Endocr J
JT  - Endocrine journal
JID - 9313485
RN  - 0 (Blood Glucose)
RN  - 0 (Chemokines)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (RARRES2 protein, human)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People
MH  - Blood Glucose
MH  - Body Mass Index
MH  - Chemokines/*blood
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Insulin Resistance
MH  - Intercellular Signaling Peptides and Proteins
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - *Sex Characteristics
EDAT- 2012/09/19 06:00
MHDA- 2013/07/23 06:00
CRDT- 2012/09/19 06:00
PHST- 2012/09/19 06:00 [entrez]
PHST- 2012/09/19 06:00 [pubmed]
PHST- 2013/07/23 06:00 [medline]
AID - DN/JST.JSTAGE/endocrj/EJ12-0201 [pii]
AID - 10.1507/endocrj.ej12-0201 [doi]
PST - ppublish
SO  - Endocr J. 2013;60(1):37-44. doi: 10.1507/endocrj.ej12-0201. Epub 2012 Oct 13.