PMID- 22986704
OWN - NLM
STAT- MEDLINE
DCOM- 20130919
LR  - 20240318
IS  - 1532-0987 (Electronic)
IS  - 0891-3668 (Print)
IS  - 0891-3668 (Linking)
VI  - 32
IP  - 3
DP  - 2013 Mar
TI  - Prevalence of human leukocyte antigen-B*5701 among HIV-infected children in 
      Thailand and Cambodia: implications for abacavir use.
PG  - 252-3
LID - 10.1097/INF.0b013e3182745dba [doi]
AB  - Human leukocyte antigen (HLA)-B*5701 allele is associated with abacavir 
      hypersensitivity. Limited data among Asians showed lower rates of HLA-B*5701 
      compared with Caucasians. In 296 children with HIV in Thailand and Cambodia, the 
      prevalence of HLA-B*5701 was 4.0% (95% confidence interval: 1.6-8.0%) among Thai 
      and 3.4% (95% confidence interval: 0.9-8.5%) among Cambodian children. HLA-B*5701 
      carriage is not uncommon among Thai and Cambodian children; it is close to the 
      prevalence found in European and higher than the prevalence found in East Asian 
      and African studies.
FAU - Puthanakit, Thanyawee
AU  - Puthanakit T
AD  - HIV Netherlands Australia Thailand (HIV-NAT) Research Collaboration, The Thai Red 
      Cross AIDS Research Center, Bangkok, Thailand. thanyawee.p@hivnat.or
FAU - Bunupuradah, Torsak
AU  - Bunupuradah T
FAU - Kosalaraksa, Pope
AU  - Kosalaraksa P
FAU - Vibol, Ung
AU  - Vibol U
FAU - Hansudewechakul, Rawiwan
AU  - Hansudewechakul R
FAU - Ubolyam, Sasiwimol
AU  - Ubolyam S
FAU - Suwanlerk, Tulathip
AU  - Suwanlerk T
FAU - Kanjanavanit, Suparat
AU  - Kanjanavanit S
FAU - Ngampiyaskul, Chaiwat
AU  - Ngampiyaskul C
FAU - Wongsawat, Jurai
AU  - Wongsawat J
FAU - Luesomboon, Wicharn
AU  - Luesomboon W
FAU - Vonthanak, Saphonn
AU  - Vonthanak S
FAU - Ananworanich, Jintanat
AU  - Ananworanich J
FAU - Ruxrungtham, Kiat
AU  - Ruxrungtham K
CN  - PREDICT Study Group
LA  - eng
GR  - R01 MH089722/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pediatr Infect Dis J
JT  - The Pediatric infectious disease journal
JID - 8701858
RN  - 0 (Dideoxynucleosides)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B*57:01 antigen)
RN  - WR2TIP26VS (abacavir)
SB  - IM
MH  - Cambodia
MH  - Child
MH  - Child, Preschool
MH  - Dideoxynucleosides/*adverse effects/*therapeutic use
MH  - Drug Hypersensitivity/*genetics
MH  - Female
MH  - Gene Frequency
MH  - HIV Infections/*drug therapy
MH  - HLA-B Antigens/*genetics
MH  - Humans
MH  - Infant
MH  - Male
MH  - Prevalence
MH  - Thailand
PMC - PMC3955121
MID - NIHMS561153
COIS- The authors have no other funding or conflicts of interest to disclose.
EDAT- 2012/09/19 06:00
MHDA- 2013/09/21 06:00
PMCR- 2014/03/15
CRDT- 2012/09/19 06:00
PHST- 2012/09/19 06:00 [entrez]
PHST- 2012/09/19 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
PHST- 2014/03/15 00:00 [pmc-release]
AID - 10.1097/INF.0b013e3182745dba [doi]
PST - ppublish
SO  - Pediatr Infect Dis J. 2013 Mar;32(3):252-3. doi: 10.1097/INF.0b013e3182745dba.