PMID- 22987447
OWN - NLM
STAT- MEDLINE
DCOM- 20140606
LR  - 20130930
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
VI  - 35
IP  - 10
DP  - 2013 Oct
TI  - New genetic findings in parotid gland pleomorphic adenomas.
PG  - 1431-8
LID - 10.1002/hed.23147 [doi]
AB  - BACKGROUND: Despite numerous studies, the tumor biology of pleomorphic adenomas, 
      the most common salivary gland tumors, is still not completely defined. In order 
      to identify further candidate genes important for tumor biology of pleomorphic 
      adenomas, extended cytogenetic and molecular analysis are mandatory. METHODS: We 
      performed a detailed molecular cytogenetic analysis using comparative genomic 
      hybridization (CGH) followed by fluorescence in situ hybridization (FISH) with 
      probes for chromosome X, 16p, 17, and 20 on a large cohort of pleomorphic 
      adenomas (n = 29). RESULTS: We could confirm previously described deletions in 
      pleomorphic adenomas affecting 16p, 17, 20q, and 22 by FISH and/or CGH analysis. 
      Moreover, our CGH study revealed novel candidate regions on 8p23.1pter, 9p, 
      10q25.1q25.3, and 11q24qter in the series of analyzed pleomorphic adenomas. 
      CONCLUSION: Our present study reveals new insights in novel candidate regions 
      implicated in pleomorphic adenoma tumorigenesis which should be considered in 
      further molecular studies.
CI  - Copyright (c) 2013 Wiley Periodicals, Inc.
FAU - Wemmert, Silke
AU  - Wemmert S
AD  - Department of Otorhinolaryngology, Saarland University Medical Center, 
      Homburg/Saar, Germany.
FAU - Willnecker, Vivienne
AU  - Willnecker V
FAU - Brunner, Christian
AU  - Brunner C
FAU - Wenzel, Gentiana Ioana
AU  - Wenzel GI
FAU - Sauter, Birgit
AU  - Sauter B
FAU - Meinelt, Heike
AU  - Meinelt H
FAU - Bartholme, Nadia
AU  - Bartholme N
FAU - Saada, Carolin
AU  - Saada C
FAU - Bohle, Rainer Maria
AU  - Bohle RM
FAU - Urbschat, Steffi
AU  - Urbschat S
FAU - Schick, Bernhard
AU  - Schick B
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20120918
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
RN  - Salivary Gland Adenoma, Pleomorphic
SB  - IM
MH  - Adenoma, Pleomorphic/*genetics/pathology/surgery
MH  - Adult
MH  - Aged
MH  - Carcinogenesis/*genetics
MH  - Chromosome Aberrations
MH  - Cohort Studies
MH  - Cytogenetic Analysis/methods
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Genetic Predisposition to Disease/*epidemiology
MH  - Genomics
MH  - Germany
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Male
MH  - Middle Aged
MH  - Parotid Neoplasms/*genetics/pathology/surgery
MH  - Preoperative Care/methods
MH  - Salivary Gland Neoplasms/*genetics/pathology/surgery
MH  - Sensitivity and Specificity
OTO - NOTNLM
OT  - CGH
OT  - FISH
OT  - genetic alterations
OT  - pleomorphic adenoma
OT  - salivary gland tumor
EDAT- 2012/09/19 06:00
MHDA- 2014/06/07 06:00
CRDT- 2012/09/19 06:00
PHST- 2012/07/11 00:00 [accepted]
PHST- 2012/09/19 06:00 [entrez]
PHST- 2012/09/19 06:00 [pubmed]
PHST- 2014/06/07 06:00 [medline]
AID - 10.1002/hed.23147 [doi]
PST - ppublish
SO  - Head Neck. 2013 Oct;35(10):1431-8. doi: 10.1002/hed.23147. Epub 2012 Sep 18.