PMID- 22989443
OWN - NLM
STAT- MEDLINE
DCOM- 20130417
LR  - 20120919
IS  - 1008-8830 (Print)
IS  - 1008-8830 (Linking)
VI  - 14
IP  - 9
DP  - 2012 Sep
TI  - [Effects of early environment on the expression of brain-derived neurotrophic 
      factor and its receptor and brain development].
PG  - 703-7
AB  - OBJECTIVE: To study the effect of early environment on the learning-memory 
      ability of rats and the expression of brain-derived neurotrophic factor (BDNF) 
      and its receptor, tyrosine kinase receptor B (TrkB), and to explore the influence 
      of early environment on development of rat brain in developing stage and possible 
      regulation mechanisms. METHODS: Forty-five newborn Sprague-Dawley rats were 
      randomly divided into three groups (15 rats in each group): enriched environment 
      group (EE group), isolated environment group (IE group) and normal control group 
      (NC group). The pups were nurtured separately in their groups. The 
      learning-memory abilities of the rats were measured by "Y"-arm maze test 28 to 29 
      days after birth. The number of neural cells and the expression of BDNF and TrkB 
      in the hippocampal CA3 and frontal lobe were were detected by Nissl's staining 
      and immunohistochemistry respectively. RESULTS: The results of the "Y"-arm maze 
      test showed that rats in the EE group needed less training times, and retained a 
      higher percentage of memory than the other two groups(P<0.01). Rats in the IE 
      group needed more training times, and retained a lower percentage of memory than 
      the NC group (P<0.01). By Nissl's staining, the numbers of neural cells in the 
      hippocampal CA3 and frontal lobe were highest in the EE group followed by the NC 
      group. They were lowest in the IE group (P<0.01). By immunohistochemistry, the 
      expression of BDNF in the hippocampal CA3 and frontal lobe were highest in the EE 
      group followed by the NC group. It was lowest in the IE group (P<0.01). Results 
      were similar for expression of TrkB. CONCLUSIONS: Early environment can affect 
      the long-term brain development and brain function of rats by influencing the 
      expression of BDNF and its receptor TrkB in the hippocampus and frontal lobe.
FAU - Chen, Jin-Lan
AU  - Chen JL
AD  - Department of Pediatrics, Union Hospital of Fujian Medical University, Fuzhou, 
      China.
FAU - Chen, Yan-Hui
AU  - Chen YH
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Dang Dai Er Ke Za Zhi
JT  - Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
JID - 100909956
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Body Weight
MH  - Brain/*growth & development
MH  - Brain-Derived Neurotrophic Factor/*analysis
MH  - Female
MH  - Hippocampus/*chemistry/pathology
MH  - Male
MH  - Maze Learning
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/*analysis
MH  - Social Isolation
EDAT- 2012/09/20 06:00
MHDA- 2013/04/18 06:00
CRDT- 2012/09/20 06:00
PHST- 2012/09/20 06:00 [entrez]
PHST- 2012/09/20 06:00 [pubmed]
PHST- 2013/04/18 06:00 [medline]
AID - 1008-8830(2012)09-0703-05 [pii]
PST - ppublish
SO  - Zhongguo Dang Dai Er Ke Za Zhi. 2012 Sep;14(9):703-7.