PMID- 22989797 OWN - NLM STAT- MEDLINE DCOM- 20150629 LR - 20121205 IS - 1308-0032 (Electronic) IS - 1302-8723 (Linking) VI - 12 IP - 8 DP - 2012 Dec TI - Brain derived neurotrophic factor (BDNF) in cardiometabolic physiology and diseases. PG - 684-8 LID - 10.5152/akd.2012.221 [doi] AB - Important advances in our understanding of the relationships between adipose tissue derived peptides, namely adipokines, and their effects on cardiovascular functions have been achieved in recent years. Growing knowledge of adipokine biology is revealing the complexity of these proteins. Adipose tissue releases some other proteins called neurotrophins that are mainly active in central and peripheral nervous system. However, secretion and activity of these hormones are not only limited to neuronal cells and tissues, but they also take part in adipose tissue development, energy metabolism, glucose utilization, insulin sensitivity, inflammation, lipoprotein synthesis, and atherosclerosis. In this review, we describe the most recent advances in the functions of brain derived nerve growth factor (BDNF), a major type of neurotrophins, focusing primarily on cardiovascular and metabolic diseases. FAU - Tasci, Ilker AU - Tasci I AD - Department of Internal Medicine, Gulhane School of Medicine, Ankara-Turkey. itasci@gata.edu.tr FAU - Kabul, Hasan Kutsi AU - Kabul HK FAU - Aydogdu, Aydogan AU - Aydogdu A LA - eng PT - Journal Article PT - Review DEP - 20120918 PL - Turkey TA - Anadolu Kardiyol Derg JT - Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology JID - 101095069 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Brain-Derived Neurotrophic Factor/*metabolism MH - Coronary Artery Disease/*metabolism MH - Coronary Vessels/*metabolism MH - Humans EDAT- 2012/09/20 06:00 MHDA- 2015/06/30 06:00 CRDT- 2012/09/20 06:00 PHST- 2012/09/20 06:00 [entrez] PHST- 2012/09/20 06:00 [pubmed] PHST- 2015/06/30 06:00 [medline] AID - 10.5152/akd.2012.221 [doi] PST - ppublish SO - Anadolu Kardiyol Derg. 2012 Dec;12(8):684-8. doi: 10.5152/akd.2012.221. Epub 2012 Sep 18.