PMID- 22991070
OWN - NLM
STAT- MEDLINE
DCOM- 20130412
LR  - 20211021
IS  - 1534-6293 (Electronic)
IS  - 1528-4042 (Linking)
VI  - 12
IP  - 6
DP  - 2012 Dec
TI  - Update on progressive multifocal leukoencephalopathy.
PG  - 680-6
LID - 10.1007/s11910-012-0313-4 [doi]
AB  - Progressive multifocal leukoencephalopathy (PML) is a severe, often fatal, 
      opportunistic viral infection of the central nervous system that is mainly seen 
      in the context of AIDS and certain monoclonal immune-suppressive therapies. The 
      causative agent, a polyoma virus, named JC virus infects only humans and there is 
      no animal model for PML. This update focuses on information gathered in recent 
      years on the pathogenesis of the disorder, on several clinical aspects associated 
      with diagnosis and therapy, and on the immune reconstitution inflammatory 
      syndrome (IRIS), a complication associated with removal of immunosuppressive 
      therapy in PML.
FAU - Steiner, Israel
AU  - Steiner I
AD  - Department of Neurology, Rabin Medical Center-Beilinson Campus, 49100 Petach 
      Tikva, Israel. isteiner@cc.huji.ac.il
FAU - Berger, Joseph R
AU  - Berger JR
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Neurol Neurosci Rep
JT  - Current neurology and neuroscience reports
JID - 100931790
RN  - 0 (Antibodies, Monoclonal, Humanized)
SB  - IM
MH  - Antibodies, Monoclonal, Humanized/adverse effects/therapeutic use
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/complications
MH  - JC Virus/drug effects/immunology
MH  - Leukoencephalopathy, Progressive Multifocal/complications/*diagnosis/*drug 
      therapy/virology
EDAT- 2012/09/20 06:00
MHDA- 2013/04/13 06:00
CRDT- 2012/09/20 06:00
PHST- 2012/09/20 06:00 [entrez]
PHST- 2012/09/20 06:00 [pubmed]
PHST- 2013/04/13 06:00 [medline]
AID - 10.1007/s11910-012-0313-4 [doi]
PST - ppublish
SO  - Curr Neurol Neurosci Rep. 2012 Dec;12(6):680-6. doi: 10.1007/s11910-012-0313-4.