PMID- 22991242
OWN - NLM
STAT- MEDLINE
DCOM- 20130709
LR  - 20220330
IS  - 1097-4644 (Electronic)
IS  - 0730-2312 (Linking)
VI  - 114
IP  - 3
DP  - 2013 Mar
TI  - Role of inflammatory mechanisms in pathogenesis of type 2 diabetes mellitus.
PG  - 525-31
LID - 10.1002/jcb.24402 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is characterized by progressive beta-cell 
      dysfunctioning and insulin resistance. This article reviews recent literature 
      with special focus on inflammatory mechanisms that provoke the pathogenesis of 
      T2DM. We have focused on the recent advances in progression of T2DM including 
      various inflammatory mechanisms that might induce inflammation, insulin 
      resistance, decrease insulin secretion from pancreatic islets and dysfunctioning 
      of beta-cells. Here we have also summarized the role of various pro-inflammatory 
      mediators involved in inflammatory mechanisms, which may further alter the normal 
      structure of beta-cells by inducing pancreatic islet's apoptosis. In conclusion, it 
      is suggested that the role of inflammation in pathogenesis of T2DM is crucial and 
      cannot be neglected. Moreover, the insight of inflammatory responses in T2DM may 
      provide a new gateway for the better treatment of diabetes mellitus.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Akash, Muhammad Sajid Hamid
AU  - Akash MS
AD  - Institute of Pharmacology, Toxicology, and Biochemical Pharmaceutics, College of 
      Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
FAU - Rehman, Kanwal
AU  - Rehman K
FAU - Chen, Shuqing
AU  - Chen S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Cell Biochem
JT  - Journal of cellular biochemistry
JID - 8205768
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Insulin)
SB  - IM
MH  - Apoptosis
MH  - Chemokines
MH  - Cytokines
MH  - Diabetes Mellitus, Type 2/immunology/*pathology
MH  - Dyslipidemias
MH  - Humans
MH  - Hyperglycemia
MH  - Inflammation/immunology/*pathology
MH  - Inflammation Mediators
MH  - Insulin/metabolism
MH  - *Insulin Resistance
MH  - Insulin Secretion
MH  - Insulin-Secreting Cells/*pathology
MH  - Oxidative Stress
EDAT- 2012/09/20 06:00
MHDA- 2013/07/10 06:00
CRDT- 2012/09/20 06:00
PHST- 2012/06/19 00:00 [received]
PHST- 2012/09/11 00:00 [accepted]
PHST- 2012/09/20 06:00 [entrez]
PHST- 2012/09/20 06:00 [pubmed]
PHST- 2013/07/10 06:00 [medline]
AID - 10.1002/jcb.24402 [doi]
PST - ppublish
SO  - J Cell Biochem. 2013 Mar;114(3):525-31. doi: 10.1002/jcb.24402.