PMID- 22992149
OWN - NLM
STAT- MEDLINE
DCOM- 20130207
LR  - 20211021
IS  - 1744-8409 (Electronic)
IS  - 1744-666X (Linking)
VI  - 8
IP  - 6
DP  - 2012 Aug
TI  - Cross presentation of antigen by dendritic cells: mechanisms and implications for 
      immunotherapy.
PG  - 547-55
AB  - Dendritic cells (DCs) possess the specialized potential to present exogenously 
      derived antigen to cytotoxic T lymphocytes to elicit an immune response. This 
      process, termed cross presentation, is crucial in the generation of immune 
      response to viruses, tumors and in autoimmune disease. The ability of DCs to 
      cross-present exogenous antigen to cytotoxic T lymphocytes makes them an 
      attractive target for exploitation in immunotherapy. In recent years, significant 
      advances have been made in understanding the mechanism of cross-presentation and 
      the DC subsets involved. The recent discovery of the human cross presenting DC 
      has given this field a new lease of life. In this report, the authors provide an 
      overview of cross-presentation of antigen by DCs, focusing on the current 
      understanding of the molecular mechanisms of the process. The authors also 
      discuss the DC subsets involved in cross presentation and its role in health and 
      disease.
FAU - Sachamitr, Patty
AU  - Sachamitr P
AD  - University of Oxford, Sir William Dunn School of Pathology, South Parks Road, 
      Oxford, UK.
FAU - Fairchild, Paul J
AU  - Fairchild PJ
LA  - eng
GR  - G0802538/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PL  - England
TA  - Expert Rev Clin Immunol
JT  - Expert review of clinical immunology
JID - 101271248
SB  - IM
MH  - Antigen Presentation/*immunology
MH  - Cross-Priming/*immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
EDAT- 2012/09/21 06:00
MHDA- 2013/02/08 06:00
CRDT- 2012/09/21 06:00
PHST- 2012/09/21 06:00 [entrez]
PHST- 2012/09/21 06:00 [pubmed]
PHST- 2013/02/08 06:00 [medline]
AID - 10.1586/eci.12.45 [doi]
PST - ppublish
SO  - Expert Rev Clin Immunol. 2012 Aug;8(6):547-55. doi: 10.1586/eci.12.45.