PMID- 22993321
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20131121
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 32
IP  - 9
DP  - 2012 Sep
TI  - The Effects of N-acetylcysteine on ifosfamide efficacy in a mouse xenograft 
      model.
PG  - 3791-8
AB  - BACKGROUND/AIM: Nephrotoxicity is observed in 30% of children treated with 
      ifosfamide. We have shown that n-acetylcysteine (NAC) successfully mitigates 
      nephrotoxicity of ifosfamide in cell and rodent models. However, before this 
      treatment is evaluated clinically, it must be established that NAC does not 
      interfere with the efficacy of ifosfamide. MATERIALS AND METHODS: Mice implanted 
      with Ewing's sarcoma tumours received the following treatments: saline, 
      ifosfamide, ifosfamide + NAC concurrently, pre-treatment with NAC + ifosfamide, 
      or NAC alone. RESULTS: Median volumes of EW-7 tumour xenografts in mice treated 
      with ifosfamide (n=8), ifosfamide with concurrent NAC therapy (n=7), and NAC 
      pre-treatment (n=6) (p<0.05) were significantly reduced compared to median tumour 
      volumes of control mice (n=6). None of the NAC treatments affected 
      ifosfamide-mediated reduction in tumour volumes. CONCLUSION: NAC does not 
      interfere with the efficacy of ifosfamide in a EW-7 xenograft model. These 
      results support the clinical evaluation of NAC as a strategy against 
      ifosfamide-induced nephrotoxicity in children.
FAU - Hanly, L
AU  - Hanly L
AD  - Department of Physiology and Pharmacology, Schulich School of Medicine and 
      Dentistry, University of Western Ontario, London, ON, Canada.
FAU - Figueredo, R
AU  - Figueredo R
FAU - Rieder, M J
AU  - Rieder MJ
FAU - Koropatnick, J
AU  - Koropatnick J
FAU - Koren, G
AU  - Koren G
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Antineoplastic Agents, Alkylating)
RN  - UM20QQM95Y (Ifosfamide)
RN  - WYQ7N0BPYC (Acetylcysteine)
SB  - IM
MH  - Acetylcysteine/*pharmacology
MH  - Animals
MH  - Antineoplastic Agents, Alkylating/*pharmacology
MH  - Bone Neoplasms/*drug therapy/pathology
MH  - Cell Growth Processes/drug effects
MH  - Cell Line, Tumor
MH  - Drug Interactions
MH  - Female
MH  - Humans
MH  - Ifosfamide/*pharmacology
MH  - Mice
MH  - Sarcoma, Ewing/*drug therapy/pathology
MH  - Treatment Outcome
MH  - Xenograft Model Antitumor Assays
EDAT- 2012/09/21 06:00
MHDA- 2013/01/05 06:00
CRDT- 2012/09/21 06:00
PHST- 2012/09/21 06:00 [entrez]
PHST- 2012/09/21 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
AID - 32/9/3791 [pii]
PST - ppublish
SO  - Anticancer Res. 2012 Sep;32(9):3791-8.