PMID- 22993422
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20231012
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 32
IP  - 38
DP  - 2012 Sep 19
TI  - MSK1 regulates homeostatic and experience-dependent synaptic plasticity.
PG  - 13039-51
AB  - The ability of neurons to modulate synaptic strength underpins synaptic 
      plasticity, learning and memory, and adaptation to sensory experience. Despite 
      the importance of synaptic adaptation in directing, reinforcing, and revising the 
      behavioral response to environmental influences, the cellular and molecular 
      mechanisms underlying synaptic adaptation are far from clear. Brain-derived 
      neurotrophic factor (BDNF) is a prime initiator of structural and functional 
      synaptic adaptation. However, the signaling cascade activated by BDNF to initiate 
      these adaptive changes has not been elucidated. We have previously shown that 
      BDNF activates mitogen- and stress-activated kinase 1 (MSK1), which regulates 
      gene transcription via the phosphorylation of both CREB and histone H3. Using 
      mice with a kinase-dead knock-in mutation of MSK1, we now show that MSK1 is 
      necessary for the upregulation of synaptic strength in response to environmental 
      enrichment in vivo. Furthermore, neurons from MSK1 kinase-dead mice failed to 
      show scaling of synaptic transmission in response to activity deprivation in 
      vitro, a deficit that could be rescued by reintroduction of wild-type MSK1. We 
      also show that MSK1 forms part of a BDNF- and MAPK-dependent signaling cascade 
      required for homeostatic synaptic scaling, which likely resides in the ability of 
      MSK1 to regulate cell surface GluA1 expression via the induction of Arc/Arg3.1. 
      These results demonstrate that MSK1 is an integral part of a signaling pathway 
      that underlies the adaptive response to synaptic and environmental experience. 
      MSK1 may thus act as a key homeostat in the activity- and experience-dependent 
      regulation of synaptic strength.
FAU - Correa, Sonia A L
AU  - Correa SA
AD  - School of Life Sciences and Molecular Organisation and Assembly in Cells, 
      University of Warwick, Coventry CV4 7AL, United Kingdom.
FAU - Hunter, Christopher J
AU  - Hunter CJ
FAU - Palygin, Oleg
AU  - Palygin O
FAU - Wauters, Sandrine C
AU  - Wauters SC
FAU - Martin, Kirsty J
AU  - Martin KJ
FAU - McKenzie, Colin
AU  - McKenzie C
FAU - McKelvey, Kim
AU  - McKelvey K
FAU - Morris, Richard G M
AU  - Morris RG
FAU - Pankratov, Yuriy
AU  - Pankratov Y
FAU - Arthur, J Simon C
AU  - Arthur JS
FAU - Frenguelli, Bruno G
AU  - Frenguelli BG
LA  - eng
GR  - BB/H018344/1/BB_/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
GR  - BB/F021445/1/BB_/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
GR  - MC_U127081014/MRC_/Medical Research Council/United Kingdom
GR  - Wellcome Trust/United Kingdom
GR  - G0700447/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, AMPA)
RN  - 0 (Sodium Channel Blockers)
RN  - 0 (activity regulated cytoskeletal-associated protein)
RN  - 147336-22-9 (Green Fluorescent Proteins)
RN  - 4368-28-9 (Tetrodotoxin)
RN  - EC 2.7.11.1 (Ribosomal Protein S6 Kinases, 90-kDa)
RN  - EC 2.7.11.1 (mitogen and stress-activated protein kinase 1)
RN  - P6W5IXV8V9 (glutamate receptor ionotropic, AMPA 2)
RN  - TFZ3H25BS1 (glutamate receptor ionotropic, AMPA 1)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor/pharmacology
MH  - Cells, Cultured
MH  - Cytoskeletal Proteins/metabolism
MH  - Dendritic Spines/physiology
MH  - Environment
MH  - Enzyme Inhibitors/pharmacology
MH  - Excitatory Postsynaptic Potentials/drug effects/genetics
MH  - Female
MH  - Gene Expression Regulation/drug effects/genetics
MH  - Green Fluorescent Proteins/genetics
MH  - Hippocampus/cytology
MH  - Homeostasis/drug effects/*genetics
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Nerve Tissue Proteins/metabolism
MH  - Neuronal Plasticity/drug effects/*genetics
MH  - Neurons/*metabolism/ultrastructure
MH  - Patch-Clamp Techniques
MH  - Point Mutation/genetics
MH  - Receptors, AMPA/metabolism
MH  - Ribosomal Protein S6 Kinases, 90-kDa/genetics/*metabolism
MH  - Signal Transduction/drug effects/genetics
MH  - Sodium Channel Blockers/pharmacology
MH  - Synapses/genetics/*physiology
MH  - Tetrodotoxin/pharmacology
MH  - Time Factors
PMC - PMC6621478
EDAT- 2012/09/21 06:00
MHDA- 2012/12/10 06:00
PMCR- 2013/03/19
CRDT- 2012/09/21 06:00
PHST- 2012/09/21 06:00 [entrez]
PHST- 2012/09/21 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PHST- 2013/03/19 00:00 [pmc-release]
AID - 32/38/13039 [pii]
AID - 3799483 [pii]
AID - 10.1523/JNEUROSCI.0930-12.2012 [doi]
PST - ppublish
SO  - J Neurosci. 2012 Sep 19;32(38):13039-51. doi: 10.1523/JNEUROSCI.0930-12.2012.