PMID- 22994155
OWN - NLM
STAT- MEDLINE
DCOM- 20130131
LR  - 20211203
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 80
IP  - 4
DP  - 2012 Oct
TI  - HLA population genetics: a Lebanese population.
PG  - 341-55
LID - 10.1111/j.1399-0039.2012.01936.x [doi]
AB  - Human leukocyte antigen (HLA) typing was done in 426 Lebanese subjects of 88 
      families, in which 347 haplotypes were identified. The A, B, C, DRB1, DRB3/4/5, 
      DQB1 and DPB1 loci were typed at high resolution. This study shows that 
      information theory, as originally developed by Claude Shannon in 1948, provides a 
      promising theoretical foundation to study the population genetics of a genetic 
      system like HLA. Although Lebanese carry HLA alleles found in other populations, 
      the association of these alleles into haplotypes is quite unique. Comparisons are 
      made with the main ethnic groups. Two haplotypes well represented in the Lebanese 
      population are not identified in any global population: L1 = A*26:01:01 - 
      B*35:01:01:01- C*04:01:01:01- DRB1*16:01:01 - DRB5*02:02 - DQB1*05:02:01 and L2 
      = A*02:02 - B*41:01- C*17:01:01:01 -DRB1*11:04:01 - DRB3*02:02:01:01- 
      DQB1*03:01:01:01. By studying linkage disequilibrium in two blocks at a time, 
      with the division of the blocks at different levels in consecutive cycles, 
      conserved haplotypes in full linkage disequilibrium come to light, such as 
      A*26:01:01- B*35:01:01:01 - C*04:01:01:01 - DRB1*16:01:01 - DRB5*02:02 - 
      DQB1*05:02:01- DPB1*03:01:01 and A*33:01:01 - B*14:02:01 - C*08:02:01 - 
      DRB1*01:02:01- DQB1*05:01:01:01 - DPB1*04:01:01:01.
CI  - (c) 2012 John Wiley & Sons A/S.
FAU - Cano, Pedro
AU  - Cano P
AD  - MD Anderson Cancer Center, Houston, TX, USA. pcano@mdanderson.org
FAU - Testi, Manuela
AU  - Testi M
FAU - Andreani, Marco
AU  - Andreani M
FAU - Khoriaty, Evelyne
AU  - Khoriaty E
FAU - Bou Monsef, Jad
AU  - Bou Monsef J
FAU - Galluccio, Tiziana
AU  - Galluccio T
FAU - Troiano, Maria
AU  - Troiano M
FAU - Fernandez-Vina, Marcelo
AU  - Fernandez-Vina M
FAU - Inati, Adlette
AU  - Inati A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
SB  - IM
MH  - *Alleles
MH  - Ethnicity/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Variation/*immunology
MH  - Genetics, Population
MH  - HLA Antigens/classification/*genetics/immunology
MH  - Haplotypes
MH  - Histocompatibility Testing
MH  - Humans
MH  - Information Theory
MH  - Lebanon
MH  - Linkage Disequilibrium
MH  - Male
MH  - Molecular Typing
EDAT- 2012/09/22 06:00
MHDA- 2013/02/01 06:00
CRDT- 2012/09/22 06:00
PHST- 2012/09/22 06:00 [entrez]
PHST- 2012/09/22 06:00 [pubmed]
PHST- 2013/02/01 06:00 [medline]
AID - 10.1111/j.1399-0039.2012.01936.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2012 Oct;80(4):341-55. doi: 10.1111/j.1399-0039.2012.01936.x.