PMID- 22995297
OWN - NLM
STAT- MEDLINE
DCOM- 20130305
LR  - 20220409
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 427
IP  - 2
DP  - 2012 Oct 19
TI  - miR-1297 mediates PTEN expression and contributes to cell progression in LSCC.
PG  - 254-60
LID - S0006-291X(12)01765-2 [pii]
LID - 10.1016/j.bbrc.2012.09.025 [doi]
AB  - MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression after 
      transcription, and are involved in cancer development. Laryngeal squamous cell 
      carcinoma (LSCC) is one of the most common malignant neoplasms with increasing 
      incidence in recent years. In this paper, we report the overexpression of 
      miR-1297 in LSCC and Hep-2 cells. In addition, PTEN was identified to be directly 
      regulated by miR-1297 through western blot and luciferase activity assay. 
      Furthermore, downregulation of miR-1297 in Hep-2 cells was shown to inhibit 
      cancer cell proliferation, migration, and tumor genesis. Our results document a 
      new epigenetic mechanism for PTEN regulation in LSCC, which is crucial for the 
      development of these tumors.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Li, Xin
AU  - Li X
AD  - Department of the Seven-year Clinical, Tianjin Medical University, 22 Qixiangtai 
      Road, Heping District, Tianjin 300070, People's Republic of China. 
      lizn0208@hotmail.com
FAU - Wang, Hong-liang
AU  - Wang HL
FAU - Peng, Xin
AU  - Peng X
FAU - Zhou, Hui-fang
AU  - Zhou HF
FAU - Wang, Xin
AU  - Wang X
LA  - eng
PT  - Journal Article
DEP - 20120917
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (MIRN1297 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - EC 3.1.3.67 (PTEN Phosphohydrolase)
RN  - EC 3.1.3.67 (PTEN protein, human)
SB  - IM
MH  - Carcinoma, Squamous Cell/genetics/metabolism/*pathology
MH  - Cell Line, Tumor
MH  - Cell Movement
MH  - Cell Proliferation
MH  - Down-Regulation
MH  - *Epigenesis, Genetic
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Laryngeal Neoplasms/genetics/metabolism/*pathology
MH  - MicroRNAs/genetics/*metabolism
MH  - PTEN Phosphohydrolase/biosynthesis/*genetics
EDAT- 2012/09/22 06:00
MHDA- 2013/03/06 06:00
CRDT- 2012/09/22 06:00
PHST- 2012/08/17 00:00 [received]
PHST- 2012/09/06 00:00 [accepted]
PHST- 2012/09/22 06:00 [entrez]
PHST- 2012/09/22 06:00 [pubmed]
PHST- 2013/03/06 06:00 [medline]
AID - S0006-291X(12)01765-2 [pii]
AID - 10.1016/j.bbrc.2012.09.025 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2012 Oct 19;427(2):254-60. doi: 
      10.1016/j.bbrc.2012.09.025. Epub 2012 Sep 17.