PMID- 22995443
OWN - NLM
STAT- MEDLINE
DCOM- 20130328
LR  - 20131121
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 144
IP  - 2
DP  - 2012 Nov 21
TI  - Ethanol extracts from Hemerocallis citrina attenuate the decreases of 
      brain-derived neurotrophic factor, TrkB levels in rat induced by corticosterone 
      administration.
PG  - 328-34
LID - S0378-8741(12)00611-3 [pii]
LID - 10.1016/j.jep.2012.09.016 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Hemerocallis citrina, a traditional herbal 
      medicine, has been used for the improvement of behavioral and emotional status in 
      Eastern-Asia countries. AIM OF THE STUDY: Our previous studies have demonstrated 
      that the ethanol extracts of H. citrina flowers (HCE) reversed the behavioral 
      alterations and monoamine neurotransmitter dysfunctions in stressed mice. 
      However, the relation of its antidepressant-like action with neurotrophic 
      molecular expressions remains unknown. MATERIALS AND METHODS: To clarify this, we 
      explored the effect of HCE (32.5, 65, 130mg/kg, p.o.) on the behavior, 
      brain-derived neurotrophic factor (BDNF) and its receptor (TrkB) in 
      depression-like rats induced by exogenous administration of the stress hormone 
      corticosterone (40mg/kg, s.c.). RESULTS: It was observed that repeated 
      administration of corticosterone induced an elevation on the serum corticosterone 
      levels, which caused the abnormalities observed in the sucrose preference test 
      and forced swimming test (FST). Administration of HCE (65 and 130mg/kg) reversed 
      the changes above and up-regulated the BDNF and TrkB receptor protein expressions 
      in the brain region of frontal cortex and hippocampus. CONCLUSION: These findings 
      confirm that HCE produce an antidepressant-like effect in corticosterone-induced 
      depression-like model of rats and this effect is at least partly mediated by 
      BDNF-TrkB signaling in the frontal cortex and hippocampus.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Yi, Li-Tao
AU  - Yi LT
AD  - Department of Chemical and Pharmaceutical Engineering, College of Chemical 
      Engineering, Huaqiao University, Xiamen, Fujian province, PR China. 
      litao.yi@yahoo.com
FAU - Li, Jing
AU  - Li J
FAU - Li, Huo-Chen
AU  - Li HC
FAU - Zhou, Ying
AU  - Zhou Y
FAU - Su, Bi-Fang
AU  - Su BF
FAU - Yang, Ke-Feng
AU  - Yang KF
FAU - Jiang, Meng
AU  - Jiang M
FAU - Zhang, Yan-Ting
AU  - Zhang YT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120918
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Plant Extracts)
RN  - 0 (RNA, Messenger)
RN  - 0 (Solvents)
RN  - 3K9958V90M (Ethanol)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/pharmacology/*therapeutic use
MH  - Behavior, Animal/drug effects
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - Corticosterone/pharmacology
MH  - Depression/*drug therapy/metabolism/physiopathology
MH  - Ethanol/chemistry
MH  - Flowers
MH  - *Hemerocallis
MH  - Male
MH  - Medicine, East Asian Traditional
MH  - *Phytotherapy
MH  - Plant Extracts/pharmacology/*therapeutic use
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/genetics
MH  - Solvents/chemistry
MH  - Stress, Psychological/drug therapy/metabolism/physiopathology
MH  - Swimming
EDAT- 2012/09/22 06:00
MHDA- 2013/03/30 06:00
CRDT- 2012/09/22 06:00
PHST- 2012/04/05 00:00 [received]
PHST- 2012/08/27 00:00 [revised]
PHST- 2012/09/06 00:00 [accepted]
PHST- 2012/09/22 06:00 [entrez]
PHST- 2012/09/22 06:00 [pubmed]
PHST- 2013/03/30 06:00 [medline]
AID - S0378-8741(12)00611-3 [pii]
AID - 10.1016/j.jep.2012.09.016 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2012 Nov 21;144(2):328-34. doi: 10.1016/j.jep.2012.09.016. Epub 
      2012 Sep 18.