PMID- 22998806
OWN - NLM
STAT- MEDLINE
DCOM- 20130418
LR  - 20131121
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 323
IP  - 1-2
DP  - 2012 Dec 15
TI  - 3 cases of primary intracranial hemorrhage associated with "Molly", a purified 
      form of 3,4-methylenedioxymethamphetamine (MDMA).
PG  - 257-60
LID - S0022-510X(12)00483-2 [pii]
LID - 10.1016/j.jns.2012.08.031 [doi]
AB  - 3,4-Methylenedioxymethamphetamine (MDMA, or "Ecstasy" in tablet form) is a 
      powerful sympathomimetic drug that is commonly perceived as safer than other 
      stimulants such as methamphetamine or cocaine. "Molly" is a purified form of MDMA 
      that is perceived by users as being even safer, as it is free of adulterants such 
      as methamphetamine. Previously, all reports of intracranial hemorrhages in MDMA 
      abusers were associated with coingestion of other sympathomimetic drugs, or with 
      pre-existing cerebrovascular lesions. We describe a series of three young, 
      otherwise healthy patients with various types of intracranial hemorrhages 
      associated with "Molly" ingestion. All three patients underwent extensive workup 
      including catheter angiography that did not demonstrate aneurysm, arteriovenous 
      malformation, or vasculitis. We suggest that even the purified form of MDMA can 
      cause serious intracranial hemorrhagic complications and should not be thought of 
      as a safe recreational drug.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Kahn, D Ethan
AU  - Kahn DE
AD  - University of Miami Miller School of Medicine, Department of Neurology, USA. 
      dkahn@med.miami.edu
FAU - Ferraro, Nicholas
AU  - Ferraro N
FAU - Benveniste, Ronald J
AU  - Benveniste RJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20120919
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (Anticoagulants)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Adult
MH  - Alcohol Drinking/adverse effects
MH  - Amphetamine-Related Disorders/*complications
MH  - Anticoagulants/adverse effects
MH  - Aspirin/adverse effects
MH  - Cerebral Angiography
MH  - Craniotomy
MH  - Decompression, Surgical
MH  - Drug Synergism
MH  - Epilepsy, Tonic-Clonic/etiology
MH  - Headache/etiology
MH  - Humans
MH  - Hydrocephalus/etiology
MH  - Intracranial Hemorrhages/*chemically induced/complications/pathology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Marijuana Abuse/complications
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*adverse effects/isolation & purification
MH  - Paresis/etiology
MH  - Photophobia/etiology
MH  - Subarachnoid Hemorrhage/chemically induced/pathology/surgery
MH  - Vomiting/etiology
MH  - Young Adult
EDAT- 2012/09/25 06:00
MHDA- 2013/04/20 06:00
CRDT- 2012/09/25 06:00
PHST- 2012/07/02 00:00 [received]
PHST- 2012/08/27 00:00 [revised]
PHST- 2012/08/30 00:00 [accepted]
PHST- 2012/09/25 06:00 [entrez]
PHST- 2012/09/25 06:00 [pubmed]
PHST- 2013/04/20 06:00 [medline]
AID - S0022-510X(12)00483-2 [pii]
AID - 10.1016/j.jns.2012.08.031 [doi]
PST - ppublish
SO  - J Neurol Sci. 2012 Dec 15;323(1-2):257-60. doi: 10.1016/j.jns.2012.08.031. Epub 
      2012 Sep 19.