PMID- 22999338 OWN - NLM STAT- MEDLINE DCOM- 20140422 LR - 20151119 IS - 1874-1754 (Electronic) IS - 0167-5273 (Linking) VI - 167 IP - 6 DP - 2013 Sep 10 TI - Circulating biomarkers of collagen type I metabolism mark the right ventricular fibrosis and adverse markers of clinical outcome in adults with repaired tetralogy of Fallot. PG - 2963-8 LID - S0167-5273(12)01088-1 [pii] LID - 10.1016/j.ijcard.2012.08.059 [doi] AB - BACKGROUND: Right ventricular (RV) fibrosis is common in patients with repaired tetralogy of Fallot (rTOF). Although accumulating evidence indicates the role of circulating biomarkers of collagen metabolism in left ventricular fibrosis, rTOF data are lacking. This study examined the expression profile and clinical relevance of circulating biomarkers of collagen type I metabolism in rTOF patients. METHODS: Serum biomarkers of collagen type I synthesis (carboxy-terminal propeptide of procollagen type I, PICP), degradation (carboxy-terminal telopeptide of collagen type I, CITP), and enzymes regulating collagen degradation (matrix metalloproteinases, and type I tissue inhibitor, TIMP-1) were measured in 70 rTOF and 91 control adults. All patients had complete clinical data and received cardiovascular magnetic resonance scans with late gadolinium enhancement (LGE). RESULTS: Compared to the controls, rTOF patients had higher PICP levels (p<0.001), PICP:CITP ratios (p<0.001), and TIMP-1 concentrations (p<0.001). Increasing PICP levels correlated with higher RV LGE scores (r=0.427, p<0.001), lower VO2max (r=-0.428, p=0.002), and larger RV volumes. Furthermore, stepwise multivariate linear regression analysis identified RV end-diastolic volume index >150mL/m(2) (beta=40.52, p=0.016), RV LGE score (beta=3.94, p=0.008), and age (beta=-1.77, p=0.011) as independent correlates of circulating PICP levels. CONCLUSIONS: Patients with rTOF exhibited a profibrotic state with excessive collagen type I synthesis and dysregulated degradation. Elevated circulating PICP levels might reflect RV fibrosis, and link to adverse markers of clinical outcome. CI - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved. FAU - Chen, Chun-An AU - Chen CA AD - Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan. FAU - Tseng, Wen-Yih Isaac AU - Tseng WY FAU - Wang, Jou-Kou AU - Wang JK FAU - Chen, Ssu-Yuan AU - Chen SY FAU - Ni, Yen-Hsuan AU - Ni YH FAU - Huang, Kuo-Chin AU - Huang KC FAU - Ho, Yi-Lwun AU - Ho YL FAU - Chang, Chung-I AU - Chang CI FAU - Chiu, Ing-Sh AU - Chiu IS FAU - Su, Mao-Yuan Marine AU - Su MY FAU - Yu, Hsi-Yu AU - Yu HY FAU - Lin, Ming-Tai AU - Lin MT FAU - Lu, Chun-Wei AU - Lu CW FAU - Wu, Mei-Hwan AU - Wu MH LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20120919 PL - Netherlands TA - Int J Cardiol JT - International journal of cardiology JID - 8200291 RN - 0 (Biomarkers) RN - 0 (Collagen Type I) SB - IM MH - Adult MH - Biomarkers/blood MH - Collagen Type I/*blood MH - Female MH - Fibrosis/blood/diagnosis MH - Heart Ventricles/metabolism/pathology MH - Humans MH - Male MH - Tetralogy of Fallot/*blood/*surgery MH - Ventricular Dysfunction, Right/*blood/*diagnosis MH - Young Adult OTO - NOTNLM OT - Cardiac fibrosis OT - Collagen OT - Magnetic resonance imaging OT - Tetralogy of Fallot EDAT- 2012/09/25 06:00 MHDA- 2014/04/23 06:00 CRDT- 2012/09/25 06:00 PHST- 2012/04/17 00:00 [received] PHST- 2012/08/21 00:00 [revised] PHST- 2012/08/31 00:00 [accepted] PHST- 2012/09/25 06:00 [entrez] PHST- 2012/09/25 06:00 [pubmed] PHST- 2014/04/23 06:00 [medline] AID - S0167-5273(12)01088-1 [pii] AID - 10.1016/j.ijcard.2012.08.059 [doi] PST - ppublish SO - Int J Cardiol. 2013 Sep 10;167(6):2963-8. doi: 10.1016/j.ijcard.2012.08.059. Epub 2012 Sep 19.