PMID- 23000024
OWN - NLM
STAT- MEDLINE
DCOM- 20130530
LR  - 20121220
IS  - 1873-2747 (Electronic)
IS  - 0361-9230 (Linking)
VI  - 90
DP  - 2013 Jan
TI  - Changes in spatial memory and BDNF expression to simultaneous dietary restriction 
      and forced exercise.
PG  - 19-24
LID - S0361-9230(12)00186-4 [pii]
LID - 10.1016/j.brainresbull.2012.08.005 [doi]
AB  - Previous literature suggests that learning and memory formation can be influenced 
      by diet and exercise. In the current study, we investigated the combined effects 
      of forced swimming exercise (FSE) and every other day fasting (EODF) on spatial 
      memory formation and on the levels of brain-derived neurotrophic factor (BDNF) in 
      the hippocampus of Wistar male rats. The radial arm water maze (RAWM) paradigm 
      was used to assess changes in learning and memory formation, whereas ELISA assay 
      was used to measure BDNF protein levels. The FSE and/or EODF were simultaneously 
      instituted for 6 weeks. Results show that FSE improved learning, short-term as 
      well as long-term memory formation, and significantly increased BDNF protein in 
      the hippocampus (p<0.05). However, EODF had no effect on either spatial learning 
      and memory formation or the levels of hippocamapal BDNF protein (p>0.05). In 
      addition, EODF did not modulate beneficial effect of swimming exercise on 
      cognitive function (p>0.05). Thus exercise enhanced, while EODF did not affect 
      spatial learning and memory formation.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Khabour, Omar F
AU  - Khabour OF
AD  - Department of Medical Laboratory Sciences, Jordan University of Science and 
      Technology, Irbid, Jordan. khabour@just.edu.jo
FAU - Alzoubi, Karem H
AU  - Alzoubi KH
FAU - Alomari, Mahmoud A
AU  - Alomari MA
FAU - Alzubi, Mohammad A
AU  - Alzubi MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120918
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Food Deprivation/*physiology
MH  - Gene Expression Regulation/physiology
MH  - Male
MH  - Maze Learning/physiology
MH  - Memory/*physiology
MH  - Physical Conditioning, Animal/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Space Perception/*physiology
MH  - Time Factors
EDAT- 2012/09/25 06:00
MHDA- 2013/06/01 06:00
CRDT- 2012/09/25 06:00
PHST- 2012/07/16 00:00 [received]
PHST- 2012/08/10 00:00 [revised]
PHST- 2012/08/16 00:00 [accepted]
PHST- 2012/09/25 06:00 [entrez]
PHST- 2012/09/25 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
AID - S0361-9230(12)00186-4 [pii]
AID - 10.1016/j.brainresbull.2012.08.005 [doi]
PST - ppublish
SO  - Brain Res Bull. 2013 Jan;90:19-24. doi: 10.1016/j.brainresbull.2012.08.005. Epub 
      2012 Sep 18.