PMID- 23000553
OWN - NLM
STAT- MEDLINE
DCOM- 20130405
LR  - 20121022
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 529
IP  - 1
DP  - 2012 Oct 31
TI  - Increased expression of interleukin-18 in the trigeminal spinal subnucleus 
      caudalis after inferior alveolar nerve injury in the rat.
PG  - 39-44
LID - S0304-3940(12)01223-2 [pii]
LID - 10.1016/j.neulet.2012.09.007 [doi]
AB  - Interleukin-18 (IL-18) is an important regulator of innate and immune responses, 
      and is known to be expressed in various types of cells and upregulated in 
      pathological conditions including tissue injury and inflammation, suggesting it 
      has both proinflammatory and compensatory roles. Here we show that IL-18 was 
      increased in microglia in the trigeminal spinal subnucleus caudalis (Vc) after 
      peripheral nerve injury. We used a trigeminal neuropathic pain model in which the 
      withdrawal threshold of maxillary whisker pad skin was significantly decreased 
      after inferior alveolar nerve transection, and observed a striking increase in 
      IL-18 expression in the Vc around the obex area from 3d and continued until 14d 
      after nerve injury. The IL-18 labeled cells were largely colocalized with Iba1, 
      suggesting this upregulation occurred in hyperactive microglia. We also found 
      that the IL-18 induction coexisted with phosphorylated p38 MAPK, indicating a 
      possible role of p38 in the regulation of IL-18. Our findings are the first 
      report that injury of trigeminal nerve induced IL-18 upregulation in activated 
      microglia in the Vc, suggesting a possible role of IL-18 in orofacial neuropathic 
      pain.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Daigo, Erina
AU  - Daigo E
AD  - Department of Anesthesiology, Osaka Dental University, Osaka, Japan.
FAU - Sakuma, Yasushi
AU  - Sakuma Y
FAU - Miyoshi, Kan
AU  - Miyoshi K
FAU - Noguchi, Koichi
AU  - Noguchi K
FAU - Kotani, Junichiro
AU  - Kotani J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120918
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Animals
MH  - Interleukin-18/*metabolism
MH  - Male
MH  - Mandibular Nerve/*metabolism
MH  - Peripheral Nerve Injuries/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Trigeminal Nerve Injuries/*metabolism
MH  - Trigeminal Nuclei/*metabolism
MH  - Up-Regulation
EDAT- 2012/09/25 06:00
MHDA- 2013/04/06 06:00
CRDT- 2012/09/25 06:00
PHST- 2012/06/26 00:00 [received]
PHST- 2012/09/04 00:00 [revised]
PHST- 2012/09/06 00:00 [accepted]
PHST- 2012/09/25 06:00 [entrez]
PHST- 2012/09/25 06:00 [pubmed]
PHST- 2013/04/06 06:00 [medline]
AID - S0304-3940(12)01223-2 [pii]
AID - 10.1016/j.neulet.2012.09.007 [doi]
PST - ppublish
SO  - Neurosci Lett. 2012 Oct 31;529(1):39-44. doi: 10.1016/j.neulet.2012.09.007. Epub 
      2012 Sep 18.