PMID- 23002445
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20220408
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 206
IP  - 11
DP  - 2012 Dec 1
TI  - Elevated interleukin 8 and T-helper 1 and T-helper 17 cytokine levels prior to 
      antiretroviral therapy in participants who developed immune reconstitution 
      inflammatory syndrome during ACTG A5164.
PG  - 1715-23
LID - 10.1093/infdis/jis604 [doi]
AB  - BACKGROUND: Immune reconstitution inflammatory syndrome (IRIS) reflects an 
      aberrant immune response that can develop in human immunodeficiency 
      virus-infected patients initiating antiretroviral therapy (ART). Its pathogenesis 
      remains unclear. METHODS: We performed a nested case-control study using 
      specimens from ACTG A5164. We compared plasma biomarkers and T-cell subsets in 19 
      IRIS and 39 control participants at study entry, ART initiation, and IRIS and 
      used conditional logistic regression to develop IRIS predictive models. We 
      evaluated the effect of corticosteroids on biomarker levels. RESULTS: Eleven and 
      8 participants developed paradoxical and unmasking IRIS, respectively, none while 
      still receiving corticosteroids. Compared to controls, cases displayed elevations 
      at study entry in interleukin (IL) 8, T-helper (Th) 1 (IL-2, interferon [IFN]-gamma, 
      tumor necrosis factor [TNF]) and Th17 (IL-17) cytokine levels that persisted 
      through ART initiation and IRIS. In logistic regression, baseline higher IFN-gamma 
      and TNF were strong predictors of IRIS. Participants who received corticosteroids 
      and later developed IRIS had marked increases in IL-6, IL-8, and IFN-gamma at the 
      time of IRIS. T-cell activation markers did not differ in cases and controls 
      prior to ART but were increased in cases at the time of IRIS. CONCLUSIONS: 
      Increased IL-8, Th1, and Th17 cytokine levels in IRIS patients precede ART 
      initiation and could help identify patient populations at higher risk for IRIS.
FAU - Grant, Philip M
AU  - Grant PM
AD  - Division of Infectious Diseases, Stanford University, Stanford, California 
      94305-5107, USA. pmgrant@stanford.edu
FAU - Komarow, Lauren
AU  - Komarow L
FAU - Lederman, Michael M
AU  - Lederman MM
FAU - Pahwa, Savita
AU  - Pahwa S
FAU - Zolopa, Andrew R
AU  - Zolopa AR
FAU - Andersen, Janet
AU  - Andersen J
FAU - Asmuth, David M
AU  - Asmuth DM
FAU - Devaraj, Sridevi
AU  - Devaraj S
FAU - Pollard, Richard B
AU  - Pollard RB
FAU - Richterman, Aaron
AU  - Richterman A
FAU - Kanthikeel, Sudheesh
AU  - Kanthikeel S
FAU - Sereti, Irini
AU  - Sereti I
LA  - eng
GR  - AI68636/AI/NIAID NIH HHS/United States
GR  - AI38858/AI/NIAID NIH HHS/United States
GR  - R01 AI077501/AI/NIAID NIH HHS/United States
GR  - ImNIH/Intramural NIH HHS/United States
GR  - U01 AI038858/AI/NIAID NIH HHS/United States
GR  - U01 AI068636/AI/NIAID NIH HHS/United States
GR  - P30 AI073961/AI/NIAID NIH HHS/United States
GR  - AI6863/AI/NIAID NIH HHS/United States
GR  - UM1 AI068636/AI/NIAID NIH HHS/United States
GR  - P30 AI050410/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
DEP - 20120921
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-8)
SB  - IM
MH  - Adult
MH  - Anti-HIV Agents/*adverse effects/*therapeutic use
MH  - Biomarkers
MH  - Case-Control Studies
MH  - Cytokines/*blood/genetics/metabolism
MH  - Gene Expression Regulation/drug effects/immunology
MH  - HIV Infections/*drug therapy
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*metabolism
MH  - Interleukin-8/*blood/genetics/metabolism
MH  - Logistic Models
MH  - Middle Aged
MH  - Risk Factors
PMC - PMC3488199
EDAT- 2012/09/25 06:00
MHDA- 2013/01/11 06:00
PMCR- 2013/12/01
CRDT- 2012/09/25 06:00
PHST- 2012/09/25 06:00 [entrez]
PHST- 2012/09/25 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
PHST- 2013/12/01 00:00 [pmc-release]
AID - jis604 [pii]
AID - 10.1093/infdis/jis604 [doi]
PST - ppublish
SO  - J Infect Dis. 2012 Dec 1;206(11):1715-23. doi: 10.1093/infdis/jis604. Epub 2012 
      Sep 21.