PMID- 2300741
OWN - NLM
STAT- MEDLINE
DCOM- 19900315
LR  - 20190828
IS  - 0162-0886 (Print)
IS  - 0162-0886 (Linking)
VI  - 12
IP  - 1
DP  - 1990 Jan-Feb
TI  - Human leukocyte antigen and leprosy: study in northern Louisiana and review.
PG  - 63-74
AB  - We examined the relationship of human leukocyte antigen (HLA) phenotype to 
      leprosy in six sporadic cases in northern Louisiana and in the world literature 
      through pooling of the results of several studies. We found that HLA antigens DR2 
      and DQwl were associated with leprosy in the six cases in northern Louisiana 
      (relative risks, 4.57 for DR2 and 4.53 for DQwl), but the results are not 
      statistically significant. We pooled the Louisiana study and other population 
      studies of HLA and leprosy. The results of the pooling show DR2 and DQwl to be 
      associated with leprosy (relative risks, 2.65 for DR2 and 2.73 for DQwl), and 
      these associations are highly statistically significant (P less than 1 x 10(-8) 
      for DR2 and P = 3.6 x 10(-8) for DQwl). Further, we pooled studies of lepromatous 
      leprosy patients vs. controls and studies of tuberculoid leprosy patients vs. 
      controls and found that DR2 and DQwl are associated with both the lepromatous and 
      the tuberculoid forms of leprosy and that these associations are statistically 
      significant. We consider the associations of DR2 and DQwl in these population 
      studies to be evidence for an HLA-associated genetic influence on susceptibility 
      to leprosy.
FAU - Todd, J R
AU  - Todd JR
AD  - Department of Medicine, Louisiana State University School of Medicine, 
      Shreveport.
FAU - West, B C
AU  - West BC
FAU - McDonald, J C
AU  - McDonald JC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Rev Infect Dis
JT  - Reviews of infectious diseases
JID - 7905878
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ1 antigen)
RN  - 0 (HLA-DR2 Antigen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chi-Square Distribution
MH  - Disease Susceptibility
MH  - Female
MH  - HLA-DQ Antigens/*analysis
MH  - HLA-DR2 Antigen/*analysis
MH  - Humans
MH  - Leprosy, Lepromatous/genetics/*immunology
MH  - Leprosy, Tuberculoid/genetics/*immunology
MH  - Louisiana
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - 10.1093/clinids/12.1.63 [doi]
PST - ppublish
SO  - Rev Infect Dis. 1990 Jan-Feb;12(1):63-74. doi: 10.1093/clinids/12.1.63.