PMID- 23009565
OWN - NLM
STAT- MEDLINE
DCOM- 20130304
LR  - 20211021
IS  - 1742-4690 (Electronic)
IS  - 1742-4690 (Linking)
VI  - 9
DP  - 2012 Sep 25
TI  - NF-kappaB activation: Tax sumoylation is out, but what about Tax ubiquitination?
PG  - 78
LID - 10.1186/1742-4690-9-78 [doi]
AB  - Activation of the NF-kappaB transcription factors by the viral protein Tax plays a 
      vital role in the pathogenesis of diseases associated with human T-cell 
      lymphotropic virus type I (HTLV-I). The Tax oncoprotein undergoes constitutive 
      K63-linked ubiquitination and sumoylation; however, the roles and molecular 
      mechanisms of these post-translational modifications in Tax-mediated NF-kappaB 
      activation are being debated. Here, we discuss our current understanding of Tax 
      activation of NF-kappaB, with a focus on the controversies and the challenges that we 
      are facing.
FAU - Xiao, Gutian
AU  - Xiao G
AD  - University of Pittsburgh Cancer Institute, University of Pittsburgh Medical 
      Centers, Pittsburgh, PA 15213, USA. xiaog2@upmc.edu
LA  - eng
GR  - R01 CA116616/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120925
PL  - England
TA  - Retrovirology
JT  - Retrovirology
JID - 101216893
RN  - 0 (Gene Products, tax)
RN  - 0 (NF-kappa B)
RN  - 0 (tax protein, Human T-lymphotrophic virus 1)
SB  - IM
MH  - Gene Products, tax/*metabolism
MH  - *Host-Pathogen Interactions
MH  - Human T-lymphotropic virus 1/*pathogenicity
MH  - Humans
MH  - Models, Biological
MH  - NF-kappa B/*immunology/*metabolism
MH  - *Sumoylation
MH  - *Ubiquitination
PMC - PMC3470980
EDAT- 2012/09/27 06:00
MHDA- 2013/03/05 06:00
PMCR- 2012/09/25
CRDT- 2012/09/27 06:00
PHST- 2012/08/13 00:00 [received]
PHST- 2012/09/05 00:00 [accepted]
PHST- 2012/09/27 06:00 [entrez]
PHST- 2012/09/27 06:00 [pubmed]
PHST- 2013/03/05 06:00 [medline]
PHST- 2012/09/25 00:00 [pmc-release]
AID - 1742-4690-9-78 [pii]
AID - 10.1186/1742-4690-9-78 [doi]
PST - epublish
SO  - Retrovirology. 2012 Sep 25;9:78. doi: 10.1186/1742-4690-9-78.