PMID- 23009895
OWN - NLM
STAT- MEDLINE
DCOM- 20130307
LR  - 20220409
IS  - 1549-4713 (Electronic)
IS  - 0161-6420 (Linking)
VI  - 120
IP  - 1
DP  - 2013 Jan
TI  - Subfoveal choroidal thickness: the Beijing Eye Study.
PG  - 175-80
LID - S0161-6420(12)00683-5 [pii]
LID - 10.1016/j.ophtha.2012.07.048 [doi]
AB  - PURPOSE: To study subfoveal choroidal thickness (SFCT) in adult Chinese subjects 
      and its correlation with ocular biometric parameters, refractive error, and age. 
      DESIGN: Population-based longitudinal study. PARTICIPANTS: The population-based 
      Beijing Eye Study 2011 included 3468 individuals with a mean age of 64.6+/-9.8 
      years (range, 50-93 years). METHODS: A detailed ophthalmic examination was 
      performed, including spectral-domain optical coherence tomography (SD-OCT) with 
      enhanced depth imaging for measurement of SFCT. MAIN OUTCOME MEASURES: Subfoveal 
      choroidal thickness. RESULTS: The SFCT measurements were available for 3233 
      subjects (93.2%). Mean SFCT was 253.8+/-107.4 mum (range, 8-854 mum). In multivariate 
      analysis, SFCT increased with younger age (P<0.001; correlation coefficient 
      r=4.12; beta coefficient=0.37), shorter axial length (P<0.001; r=44.7; beta 
      coefficient=0.46), male gender (P<0.001; r=28.5; beta coefficient=-0.13), deeper 
      anterior chamber depth (P<0.001; r=39.3; beta coefficient=0.13), thicker lens 
      (P<0.001; r=26.8; beta coefficient=0.08), flatter cornea (P<0.001; r=46.0; beta 
      coefficient=0.11), and better best-corrected visual acuity (BCVA) (logarithm of 
      minimal angle of resolution; P=0.001; r=48.4; beta coefficient=0.06). In 
      multivariate analysis, SFCT was not significantly associated with blood pressure, 
      ocular perfusion pressure, intraocular pressure, cigarette smoking, alcohol 
      consumption, serum concentrations of lipids and glucose, diabetes mellitus, and 
      arterial hypertension. In the myopic refractive error range of more than -1 
      diopter (D), SFCT decreased by 15 mum (95% confidence interval [CI], 11.9-18.5) 
      for every increase in myopic refractive error of 1 D, or by 32 mum (95% CI, 
      37.1-26.0) for every increase in axial length of 1 mm. For each year increase in 
      age, the SFCT decreased by 4.1 mum (95% CI, 4.6-3.7) (multivariate analysis). 
      CONCLUSIONS: Subfoveal choroidal thickness with a mean of 254+/-107 mum in elderly 
      subjects with a mean age of 65 years decreased with age (4 mum per year of age) 
      and myopia (15 mum per diopter [D] of myopia). It was also associated with male 
      gender and the ocular biometric parameters of a deeper anterior chamber and 
      thicker lens. The association between SFCT and BCVA indicates a functional aspect 
      of SFCT. FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial 
      interest in any materials discussed in this article.
CI  - Copyright (c) 2013 American Academy of Ophthalmology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Wei, Wen Bin
AU  - Wei WB
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 
      Beijing, China. wenbing_wei@yahoo.com.cn
FAU - Xu, Liang
AU  - Xu L
FAU - Jonas, Jost B
AU  - Jonas JB
FAU - Shao, Lei
AU  - Shao L
FAU - Du, Kui Fang
AU  - Du KF
FAU - Wang, Shuang
AU  - Wang S
FAU - Chen, Chang Xi
AU  - Chen CX
FAU - Xu, Jie
AU  - Xu J
FAU - Wang, Ya Xing
AU  - Wang YX
FAU - Zhou, Jin Qiong
AU  - Zhou JQ
FAU - You, Qi Sheng
AU  - You QS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120923
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/physiology
MH  - Biometry
MH  - China
MH  - Choroid/*anatomy & histology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Fovea Centralis/anatomy & histology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myopia/physiopathology
MH  - Organ Size
MH  - Rural Population/statistics & numerical data
MH  - Sex Factors
MH  - *Tomography, Optical Coherence
MH  - Urban Population/statistics & numerical data
EDAT- 2012/09/27 06:00
MHDA- 2013/03/08 06:00
CRDT- 2012/09/27 06:00
PHST- 2012/04/05 00:00 [received]
PHST- 2012/05/15 00:00 [revised]
PHST- 2012/07/17 00:00 [accepted]
PHST- 2012/09/27 06:00 [entrez]
PHST- 2012/09/27 06:00 [pubmed]
PHST- 2013/03/08 06:00 [medline]
AID - S0161-6420(12)00683-5 [pii]
AID - 10.1016/j.ophtha.2012.07.048 [doi]
PST - ppublish
SO  - Ophthalmology. 2013 Jan;120(1):175-80. doi: 10.1016/j.ophtha.2012.07.048. Epub 
      2012 Sep 23.