PMID- 23010041
OWN - NLM
STAT- MEDLINE
DCOM- 20130509
LR  - 20181202
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 101
DP  - 2013 Jan 1
TI  - Pharmacokinetics of curcumin-loaded PLGA and PLGA-PEG blend nanoparticles after 
      oral administration in rats.
PG  - 353-60
LID - S0927-7765(12)00365-7 [pii]
LID - 10.1016/j.colsurfb.2012.06.024 [doi]
AB  - The aim of this study was to assess the potential of nanoparticles to improve the 
      pharmacokinetics of curcumin, with a primary goal of enhancing its 
      bioavailability. Polylactic-co-glycolic acid (PLGA) and PLGA-polyethylene glycol 
      (PEG) (PLGA-PEG) blend nanoparticles containing curcumin were obtained by a 
      single-emulsion solvent-evaporation technique, resulting in particles size 
      smaller than 200 nm. The encapsulation efficiency was over 70% for both 
      formulations. The in vitro release study showed that curcumin was released more 
      slowly from the PLGA nanoparticles than from the PLGA-PEG nanoparticles. A 
      LC-MS/MS method was developed and validated to quantify curcumin in rat plasma. 
      The nanoparticles were orally administered at a single dose in rats, and the 
      pharmacokinetic parameters were evaluated and compared with the curcumin aqueous 
      suspension. It was observed that both nanoparticles formulations were able to 
      sustain the curcumin delivery over time, but greater efficiency was obtained with 
      the PLGA-PEG nanoparticles, which showed better results in all of the 
      pharmacokinetic parameters analyzed. The PLGA and PLGA-PEG nanoparticles 
      increased the curcumin mean half-life in approximately 4 and 6h, respectively, 
      and the C(max) of curcumin increased 2.9- and 7.4-fold, respectively. The 
      distribution and metabolism of curcumin decreased when it was carried by 
      nanoparticles, particularly PLGA-PEG nanoparticles. The bioavailability of 
      curcumin-loaded PLGA-PEG nanoparticles was 3.5-fold greater than the curcumin 
      from PLGA nanoparticles. Compared to the curcumin aqueous suspension, the PLGA 
      and PLGA-PEG nanoparticles increased the curcumin bioavailability by 15.6- and 
      55.4-fold, respectively. These results suggest that PLGA and, in particular, 
      PLGA-PEG blend nanoparticles are potential carriers for the oral delivery of 
      curcumin.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Khalil, Najeh Maissar
AU  - Khalil NM
AD  - Department of Pharmacy, Universidade Estadual do Centro-Oeste/UNICENTRO, 
      Guarapuava, PR, Brazil.
FAU - do Nascimento, Thuane Castro Frabel
AU  - do Nascimento TC
FAU - Casa, Diani Meza
AU  - Casa DM
FAU - Dalmolin, Luciana Facco
AU  - Dalmolin LF
FAU - de Mattos, Ana Cristina
AU  - de Mattos AC
FAU - Hoss, Ivonete
AU  - Hoss I
FAU - Romano, Marco Aurelio
AU  - Romano MA
FAU - Mainardes, Rubiana Mara
AU  - Mainardes RM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120628
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Excipients)
RN  - 0 (poly(lactic-glycolic acid)-poly(ethyleneglycol) copolymer)
RN  - 34346-01-5 (Polyglactin 910)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Biological Availability
MH  - Chromatography, High Pressure Liquid
MH  - Curcumin/administration & dosage/*pharmacokinetics
MH  - Drug Compounding
MH  - Excipients
MH  - Male
MH  - Nanoparticles
MH  - Particle Size
MH  - Polyethylene Glycols
MH  - Polyglactin 910
MH  - Quality Control
MH  - Rats
MH  - Rats, Wistar
MH  - Reproducibility of Results
EDAT- 2012/09/27 06:00
MHDA- 2013/05/10 06:00
CRDT- 2012/09/27 06:00
PHST- 2012/03/02 00:00 [received]
PHST- 2012/06/10 00:00 [revised]
PHST- 2012/06/12 00:00 [accepted]
PHST- 2012/09/27 06:00 [entrez]
PHST- 2012/09/27 06:00 [pubmed]
PHST- 2013/05/10 06:00 [medline]
AID - S0927-7765(12)00365-7 [pii]
AID - 10.1016/j.colsurfb.2012.06.024 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2013 Jan 1;101:353-60. doi: 
      10.1016/j.colsurfb.2012.06.024. Epub 2012 Jun 28.