PMID- 23010200
OWN - NLM
STAT- MEDLINE
DCOM- 20130116
LR  - 20221207
IS  - 1879-0038 (Electronic)
IS  - 0378-1119 (Linking)
VI  - 512
IP  - 1
DP  - 2013 Jan 1
TI  - Association of TCF7L2 gene polymorphisms with type 2 diabetes mellitus in Han 
      Chinese population: a meta-analysis.
PG  - 76-81
LID - S0378-1119(12)01115-8 [pii]
LID - 10.1016/j.gene.2012.09.034 [doi]
AB  - Variants of transcription factor 7-like 2 (TCF7L2) gene have been reported to be 
      associated with type 2 diabetes mellitus (T2DM), but the available data on this 
      relationship are inconsistent in Han Chinese populations. A meta-analysis was 
      performed to quantitatively analyze the association of TCF7L2 gene polymorphisms 
      with T2DM using previous case-control studies in Chinese Han populations. Several 
      electronic databases were searched for relevant articles up to May 2012. After 
      data collection and gene loci selection, a meta-analysis was performed to assess 
      heterogeneity, combine results and evaluate variations. Publication bias was 
      examined by the Egger's linear regression test. Hardy-Weinberg equilibrium (HWE) 
      test and by omitting one study at a time were employed for the sensitivity 
      analysis. Eighteen studies from sixteen eligible papers were included in the 
      meta-analysis. Ten eligible studies were analyzed for rs7903146, and eight were 
      analyzed for rs290487. We found that the rs7903146 T allele was associated with 
      an increased risk for T2DM under a dominant model, a co-dominant model and an 
      allele contrast model, with an OR of 1.54 (1.32, 1.79), an OR of 1.53 (1.31, 
      1.79) and an OR of 1.52 (1.31, 1.76), respectively. The rs290487 C allele showed 
      no significant overall association with T2DM, yielding ORs of 1.08 (0.88, 1.32) 
      under a dominant model, with strong evidence of heterogeneity. Similar results 
      were also obtained in other genetic models. Sensitivity analysis confirmed the 
      reliability and stability of this meta-analysis. The accumulated evidence 
      suggested that the rs7903146 T allele was associated with an increased risk for 
      T2DM, but the rs290487 C allele is not associated with T2DM in the Chinese Han 
      population. More well-designed large studies are required for the validation of 
      this association.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Zhang, Bu-Chun
AU  - Zhang BC
AD  - Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University 
      School of Medicine, Shanghai 200072, China.
FAU - Li, Wei-Ming
AU  - Li WM
FAU - Zhu, Meng-Yun
AU  - Zhu MY
FAU - Xu, Ya-Wei
AU  - Xu YW
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20120923
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (Transcription Factor 7-Like 2 Protein)
SB  - IM
MH  - Alleles
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - China
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - *Polymorphism, Single Nucleotide
MH  - Publication Bias
MH  - Transcription Factor 7-Like 2 Protein/*genetics
EDAT- 2012/09/27 06:00
MHDA- 2013/01/17 06:00
CRDT- 2012/09/27 06:00
PHST- 2012/06/29 00:00 [received]
PHST- 2012/08/17 00:00 [revised]
PHST- 2012/09/06 00:00 [accepted]
PHST- 2012/09/27 06:00 [entrez]
PHST- 2012/09/27 06:00 [pubmed]
PHST- 2013/01/17 06:00 [medline]
AID - S0378-1119(12)01115-8 [pii]
AID - 10.1016/j.gene.2012.09.034 [doi]
PST - ppublish
SO  - Gene. 2013 Jan 1;512(1):76-81. doi: 10.1016/j.gene.2012.09.034. Epub 2012 Sep 23.