PMID- 23010479
OWN - NLM
STAT- MEDLINE
DCOM- 20130215
LR  - 20121012
IS  - 1873-376X (Electronic)
IS  - 1570-0232 (Linking)
VI  - 907
DP  - 2012 Oct 15
TI  - Analysis of daidzein in nanoparticles after oral co-administration with sodium 
      caprate to rats by ultra-performance liquid 
      chromatography-quadrupole-time-of-flight mass spectrometry.
PG  - 21-6
LID - S1570-0232(12)00498-9 [pii]
LID - 10.1016/j.jchromb.2012.08.026 [doi]
AB  - An ultra-performance-liquid-chromatography-quadrupole-time-of-flight mass 
      spectrometry (UPLC/Q-TOF-MS) method was developed and validated for the 
      quantitation of daidzein (DZ) in rat plasma. Ethylparaben was chosen as internal 
      standards (IS). DZ was linear over the range of 0.001-5 mug/mL. The lower limit of 
      quantification (LLOQ) was 0.001 mug/mL and the limit of detection (LOD) was 0.0005 
      mug/mL. The intra-day and inter-day relative standard deviations (RSDs) were 
      ranged from 3.59% to 6.43% and 5.35% to 7.25%, respectively. This UPLC/Q-TOF-MS 
      method provided good specifity, highly sensitivity, accurate and high-speed 
      detection (6 min), applicable to the pharmacokinetics study in rats in vivo after 
      oral administration of free daidzein solution, daidzein-loaded poly 
      (lactide-co-glycolide) (PLGA) nanoparticles (D-NPs) suspension and D-NPs 
      co-administered with sodium caprate (C(10)) which as the oral absorption 
      promoter. It was shown that the pharmacokinetics behavior was significantly 
      improved after the oral administration of D-NPs suspension co-administered with 
      absorption promoter C(10) by the fact that the relative bioavailability were 
      enhanced about 4.24-fold, compared to that of DZ suspension.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Ma, Yiran
AU  - Ma Y
AD  - School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
FAU - Zhang, Li
AU  - Zhang L
FAU - Zhao, Xinyi
AU  - Zhao X
FAU - Shen, Qi
AU  - Shen Q
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120910
PL  - Netherlands
TA  - J Chromatogr B Analyt Technol Biomed Life Sci
JT  - Journal of chromatography. B, Analytical technologies in the biomedical and life 
      sciences
JID - 101139554
RN  - 0 (Decanoic Acids)
RN  - 0 (Isoflavones)
RN  - 4G9EDB6V73 (decanoic acid)
RN  - 6287WC5J2L (daidzein)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Decanoic Acids/*administration & dosage/pharmacokinetics
MH  - Drug Stability
MH  - Isoflavones/administration & dosage/*blood/pharmacokinetics
MH  - Linear Models
MH  - Male
MH  - Mass Spectrometry/*methods
MH  - Nanoparticles/*administration & dosage/chemistry
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
EDAT- 2012/09/27 06:00
MHDA- 2013/02/16 06:00
CRDT- 2012/09/27 06:00
PHST- 2012/02/06 00:00 [received]
PHST- 2012/08/21 00:00 [revised]
PHST- 2012/08/23 00:00 [accepted]
PHST- 2012/09/27 06:00 [entrez]
PHST- 2012/09/27 06:00 [pubmed]
PHST- 2013/02/16 06:00 [medline]
AID - S1570-0232(12)00498-9 [pii]
AID - 10.1016/j.jchromb.2012.08.026 [doi]
PST - ppublish
SO  - J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Oct 15;907:21-6. doi: 
      10.1016/j.jchromb.2012.08.026. Epub 2012 Sep 10.