PMID- 23011573
OWN - NLM
STAT- MEDLINE
DCOM- 20130806
LR  - 20181202
IS  - 1533-4112 (Electronic)
IS  - 1095-0680 (Linking)
VI  - 29
IP  - 1
DP  - 2013 Mar
TI  - Prevention of relapse with maintenance electroconvulsive therapy in elderly 
      patients with major depressive episode.
PG  - 61-4
LID - 10.1097/YCT.0b013e31826d369a [doi]
AB  - OBJECTIVES: To evaluate the effectiveness and safety of maintenance 
      electroconvulsive therapy (mECT) in elderly patients with treatment-resistant 
      Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition major 
      depressive episode. METHODS: Seven elderly patients with treatment-resistant 
      major depressive episode were treated with a complete ECT cycle. Thereafter, they 
      received one monthly ECT session as maintenance for 1 year. Response to treatment 
      was defined as at least a 50% drop from baseline on the Hamilton Depression 
      Rating Scale (HamD) and remission as not meeting criteria for major depression, a 
      HamD score of 7 or less, and Clinical Global Impressions-Severity of Illness 
      score of 1. We compared their response with the response of 7 elderly patients 
      with treatment-resistant major depression who were treated with a full cycle of 
      ECT but did not receive mECT (non-mECT). We compared the 2 groups for the number 
      of relapses or recurrences of major depressive episodes after remission was 
      achieved; a relapse or a recurrence occurred when HamD scores were 14 or higher, 
      or when Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, 
      Text Revision major depressive episode criteria were met, or when Clinical Global 
      Impressions-Severity of Illness score was 3 or higher and increased by at least 2 
      points from response/remission. RESULTS: The mECT group (4 women and 3 men; mean 
      age, 73 years) had significantly less mean relapses/recurrences (0 vs 1.57) and 
      hospitalizations (0 vs 1) and received less drug treatment than the nonMECT group 
      (similar for age and sex composition) during the 12-month follow-up period. All 
      patients with mECT improved during treatment and did not relapse. CONCLUSIONS: 
      Maintenance ECT protected elderly patients from recurrent depressive episodes 
      from relapsing/recurring more than standard ECT.
FAU - Rapinesi, Chiara
AU  - Rapinesi C
AD  - NESMOS Department (Neurosciences, Mental Health, and Sensory Organs), Sapienza 
      University of Rome, School of Medicine and Psychology, Sant'Andrea Hospital, 
      Rome, Italy.
FAU - Kotzalidis, Georgios Demetrios
AU  - Kotzalidis GD
FAU - Serata, Daniele
AU  - Serata D
FAU - Del Casale, Antonio
AU  - Del Casale A
FAU - Scatena, Paola
AU  - Scatena P
FAU - Mazzarini, Lorenzo
AU  - Mazzarini L
FAU - Caccia, Federica
AU  - Caccia F
FAU - Brugnoli, Roberto
AU  - Brugnoli R
FAU - Carbonetti, Paolo
AU  - Carbonetti P
FAU - Fensore, Claudio
AU  - Fensore C
FAU - Girardi, Paolo
AU  - Girardi P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J ECT
JT  - The journal of ECT
JID - 9808943
RN  - 0 (Antipsychotic Agents)
RN  - 12794-10-4 (Benzodiazepines)
RN  - N7U69T4SZR (Olanzapine)
SB  - IM
MH  - Aged
MH  - Antipsychotic Agents/therapeutic use
MH  - Benzodiazepines/therapeutic use
MH  - Depressive Disorder, Major/psychology/*therapy
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Electroconvulsive Therapy/*methods
MH  - Female
MH  - Hospitalization
MH  - Humans
MH  - Male
MH  - Olanzapine
MH  - Psychiatric Status Rating Scales
MH  - Secondary Prevention
MH  - Severity of Illness Index
MH  - Treatment Outcome
EDAT- 2012/09/27 06:00
MHDA- 2013/08/07 06:00
CRDT- 2012/09/27 06:00
PHST- 2012/09/27 06:00 [entrez]
PHST- 2012/09/27 06:00 [pubmed]
PHST- 2013/08/07 06:00 [medline]
AID - 10.1097/YCT.0b013e31826d369a [doi]
PST - ppublish
SO  - J ECT. 2013 Mar;29(1):61-4. doi: 10.1097/YCT.0b013e31826d369a.