PMID- 23013043
OWN - NLM
STAT- MEDLINE
DCOM- 20121207
LR  - 20120927
IS  - 1470-8736 (Electronic)
IS  - 0143-5221 (Linking)
VI  - 124
IP  - 2
DP  - 2013 Jan
TI  - Circulating adipocyte fatty acid-binding protein levels are independently 
      associated with heart failure.
PG  - 115-22
AB  - A-FABP (adipocyte fatty acid-binding protein), one of the most abundant proteins 
      in adipocytes, plays a key role in obesity-related insulin resistance, 
      inflammation and atherosclerosis in animals. In the present study, we sought to 
      investigate the association of A-FABP with HF (heart failure) in Chinese 
      subjects. Serum A-FABP levels were measured in 252 HF patients and 261 age-, 
      gender- and BMI (body mass index)-matched non-HF subjects. Echocardiography was 
      performed on each patient. The severity of HF was determined by the NYHA (New 
      York Heart Association) classification system. After adjustments for age, gender 
      and BMI, serum A-FABP concentrations in patients with HF were significantly 
      higher than in non-HF patients [11.17 (6.63-19.93) ng/ml compared with 5.67 
      (3.20-8.87) ng/ml; P<0.001] and significantly progressed with the NYHA class 
      (P<0.001). In addition, NT-proBNP (N-terminal pro-brain natriuretic peptide) was 
      independently and positively correlated with A-FABP (standardized beta=0.340, 
      P<0.001) after adjusting for confounding factors. Each echocardiographic 
      parameter, especially LVEF (left ventricular ejection fraction), was 
      independently associated with A-FABP (all P<0.05). Multivariate logistic 
      regression analysis demonstrated that A-FABP concentration was an independent 
      risk factor for HF [odds ratio, 6.93 (95% confidence interval, 2.49-19.30); 
      P<0.001]. Our results demonstrate that A-FABP is closely associated with HF, and 
      raise the possibility that increased A-FABP may be causally related to the 
      pathogenesis of heart dysfunction in humans.
FAU - Liu, Mingya
AU  - Liu M
AD  - Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's 
      Hospital, Shanghai, People's Republic of China.
FAU - Zhou, Mi
AU  - Zhou M
FAU - Bao, Yuqian
AU  - Bao Y
FAU - Xu, Zhiyong
AU  - Xu Z
FAU - Li, Huating
AU  - Li H
FAU - Zhang, Hao
AU  - Zhang H
FAU - Zhu, Wei
AU  - Zhu W
FAU - Zhang, Jialiang
AU  - Zhang J
FAU - Xu, Aimin
AU  - Xu A
FAU - Wei, Meng
AU  - Wei M
FAU - Jia, Weiping
AU  - Jia W
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Sci (Lond)
JT  - Clinical science (London, England : 1979)
JID - 7905731
RN  - 0 (FABP4 protein, human)
RN  - 0 (Fatty Acid-Binding Proteins)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Anthropometry
MH  - Body Mass Index
MH  - China
MH  - Cohort Studies
MH  - Echocardiography
MH  - Fatty Acid-Binding Proteins/*blood
MH  - Female
MH  - Heart Failure/*blood
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Sex Factors
EDAT- 2012/09/28 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/09/28 06:00
PHST- 2012/09/28 06:00 [entrez]
PHST- 2012/09/28 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - CS20120004 [pii]
AID - 10.1042/CS20120004 [doi]
PST - ppublish
SO  - Clin Sci (Lond). 2013 Jan;124(2):115-22. doi: 10.1042/CS20120004.