PMID- 23014255
OWN - NLM
STAT- MEDLINE
DCOM- 20130425
LR  - 20120927
IS  - 1878-0334 (Electronic)
IS  - 1871-4021 (Linking)
VI  - 6
IP  - 1
DP  - 2012 Jan-Mar
TI  - Relationship of transcription factor 7 like 2 gene rs7903146 variation with type 
      2 diabetes and obesity related parameters.
PG  - 48-53
LID - S1871-4021(12)00064-1 [pii]
LID - 10.1016/j.dsx.2012.05.002 [doi]
AB  - AIMS: The allele frequencies of transcription factor 7 like 2 (TCF7L2) gene 
      rs7903146 polymorphism in type 2 diabetes mellitus (T2DM) and non-T2DM controls 
      were determined. METHODS: TCF7L2 rs7903146 genotypes were determined with qPCR. 
      RESULTS: The TCF7L2 gene rs7903146 genotype frequencies for homozygous wild type 
      (C/C), heterozygous (C/T) and homozygous polymorphic (T/T) for T2DM patients were 
      determined, respectively, as 71.4%, 14.3%, 14.3% and 72.5%, 11.8%, 15.7% for 
      controls. The weight, length and lean body mass were higher in C/T+T/T compared 
      to C/C carriers. Glucose, insulin, insulin resistance and homeostatic model 
      assessment (HOMA) were nonsignificantly higher in rs7903146C/T+T/T in comparison 
      to C/C. TCF7L2 gene rs7903146 genotypes were not found to interact with drugs. 
      The absence of any difference between genotype frequencies among study groups 
      indicates that no association persists with TCF7L2 gene rs7903146 polymorphism 
      and T2DM. CONCLUSIONS: The effects of rs7903146 variation over some obesity 
      variables suggest that this variation may effect T2DM development via obesity.
CI  - Copyright (c) 2012 Diabetes India. Published by Elsevier Ltd. All rights reserved.
FAU - Kahveci, Cigdem
AU  - Kahveci C
AD  - Marmara University, Faculty of Science and Arts, Department of Biology, Istanbul, 
      Turkey.
FAU - Koldemir, Meliha
AU  - Koldemir M
FAU - Cagatay, Penbe
AU  - Cagatay P
FAU - Bayer, Hikmet
AU  - Bayer H
FAU - Yildiz, Sema
AU  - Yildiz S
FAU - Bagriacik, Nazif
AU  - Bagriacik N
FAU - Duman, Belgin Susleyici
AU  - Duman BS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120605
PL  - Netherlands
TA  - Diabetes Metab Syndr
JT  - Diabetes & metabolic syndrome
JID - 101462250
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (TCF7L2 protein, human)
RN  - 0 (Transcription Factor 7-Like 2 Protein)
SB  - IM
MH  - Blood Glucose/metabolism
MH  - Body Weights and Measures
MH  - Comorbidity
MH  - DNA Mutational Analysis
MH  - Diabetes Mellitus, Type 2/diagnosis/epidemiology/*genetics
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Insulin/blood
MH  - Insulin Resistance/genetics
MH  - Male
MH  - Middle Aged
MH  - Obesity/diagnosis/epidemiology/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Transcription Factor 7-Like 2 Protein/*genetics
EDAT- 2012/09/28 06:00
MHDA- 2013/04/26 06:00
CRDT- 2012/09/28 06:00
PHST- 2012/09/28 06:00 [entrez]
PHST- 2012/09/28 06:00 [pubmed]
PHST- 2013/04/26 06:00 [medline]
AID - S1871-4021(12)00064-1 [pii]
AID - 10.1016/j.dsx.2012.05.002 [doi]
PST - ppublish
SO  - Diabetes Metab Syndr. 2012 Jan-Mar;6(1):48-53. doi: 10.1016/j.dsx.2012.05.002. 
      Epub 2012 Jun 5.