PMID- 23015046
OWN - NLM
STAT- MEDLINE
DCOM- 20130702
LR  - 20211021
IS  - 1432-1076 (Electronic)
IS  - 0340-6199 (Linking)
VI  - 172
IP  - 1
DP  - 2013 Jan
TI  - Association of adipokines with cardiovascular risk factors in low birth weight 
      children: a case-control study.
PG  - 71-6
LID - 10.1007/s00431-012-1846-x [doi]
AB  - Our aim was to investigate plasma levels of adiponectin, monocyte chemoattractant 
      protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in low birth 
      weight (LBW) children and to determine correlations among these adipokines and 
      birth weight and cardiovascular disease risk factors. In a case-control study, 
      the concentrations of adiponectin, MCP-1 and PAI-1 were measured in 180 
      schoolchildren (ages 6-11 years). MCP-1 and PAI-1 levels were significantly 
      elevated in LBW children. Conversely, adiponectin concentration was significantly 
      reduced in these children. Similar findings were observed after adjustment for 
      current age, gender and abdominal circumference. Because the children with LBW 
      had altered adipokine levels, as well as higher abdominal circumference, HOMA-IR 
      and systolic blood pressure (SBP), we evaluated the correlation among these 
      variables. These analyses showed that adiponectin levels were inversely 
      correlated with systolic blood pressure (SBP) (r = -0.501; P < 0.001), HOMA-IR 
      (r = -0.293; P = 0.023) and waist circumference (r = -0.317; P = 0.014). The 
      proinflammatory markers were positively correlated with HOMA-IR (PAI-1: 
      r = 0.358; P = 0.005) and waist circumference (PAI-1: r = 0.571; P < 0.001 and 
      MCP-1: r = 0.267; P = 0.039). CONCLUSION: Adipokines levels were correlated with 
      cardiovascular risk factors in LBW children, and these compounds could be 
      involved in the mechanism that links birth weight to the development of 
      cardiovascular diseases in adulthood.
FAU - Strufaldi, Maria Wany Louzada
AU  - Strufaldi MW
AD  - Department of Pediatrics, School of Medicine, Federal University of Sao Paulo, 
      Rua Botucatu, 598 Sao Paulo, Brazil. mwany@uol.com.br
FAU - Puccini, Rosana Fiorini
AU  - Puccini RF
FAU - Silverio, Olga Maria Amancio
AU  - Silverio OM
FAU - do Pinho Franco, Maria Carmo
AU  - do Pinho Franco MC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120927
PL  - Germany
TA  - Eur J Pediatr
JT  - European journal of pediatrics
JID - 7603873
RN  - 0 (Adipokines)
RN  - 0 (Adiponectin)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Plasminogen Activator Inhibitor 1)
SB  - IM
MH  - Adipokines/*blood
MH  - Adiponectin/*blood
MH  - Blood Pressure
MH  - Cardiovascular Diseases/*epidemiology
MH  - Case-Control Studies
MH  - Chemokine CCL2/*blood
MH  - Child
MH  - Female
MH  - Humans
MH  - Infant, Low Birth Weight
MH  - Infant, Newborn
MH  - Male
MH  - Plasminogen Activator Inhibitor 1/*blood
MH  - Risk Factors
EDAT- 2012/09/28 06:00
MHDA- 2013/07/03 06:00
CRDT- 2012/09/28 06:00
PHST- 2012/07/06 00:00 [received]
PHST- 2012/09/17 00:00 [accepted]
PHST- 2012/08/19 00:00 [revised]
PHST- 2012/09/28 06:00 [entrez]
PHST- 2012/09/28 06:00 [pubmed]
PHST- 2013/07/03 06:00 [medline]
AID - 10.1007/s00431-012-1846-x [doi]
PST - ppublish
SO  - Eur J Pediatr. 2013 Jan;172(1):71-6. doi: 10.1007/s00431-012-1846-x. Epub 2012 
      Sep 27.