PMID- 2301648
OWN - NLM
STAT- MEDLINE
DCOM- 19900305
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 258
IP  - 1 Pt 2
DP  - 1990 Jan
TI  - Electrophysiological evidence that systemic angiotensin influences rat area 
      postrema neurons.
PG  - R70-6
AB  - Extracellular single-unit recordings from neurons in the area postrema (AP) and 
      the nucleus tractus solitarius (NTS) in anesthetized male rats demonstrated that 
      most cells in these regions have spontaneous activities of 5 Hz or less. Systemic 
      angiotensin (ANG II) (50-500 ng) enhanced the activity of 55% of AP cells tested 
      (n = 76), whereas 53% of tested NTS neurons (n = 62) were inhibited by ANG II. To 
      determine whether these neurons were influenced specifically by circulating ANG 
      II or by the accompanying increase in mean arterial blood pressure (BP), the 
      effects of adrenergic agonists given intravenously on ANG II influenced neurons 
      were also examined. Subsequently two cell types were characterized: cells 
      responding to iv ANG II but not to the adrenergic agonist ("ANG II sensitive") 
      and cells responding in a similar way to both agents ("BP sensitive"). Most ANG 
      II-responsive neurons in the AP (53.5%) and the NTS (65%) were determined to be 
      BP sensitive. These data demonstrate that ANG II influences the activity of AP 
      neurons. In addition, there exists a second population of AP neurons apparently 
      responsive to perturbations of the cardiovascular system. These studies further 
      emphasize the potential roles of the AP in the regulation of body fluid balance.
FAU - Papas, S
AU  - Papas S
AD  - Department of Physiology, Queen's University, Kingston, Ontario, Canada.
FAU - Smith, P
AU  - Smith P
FAU - Ferguson, A V
AU  - Ferguson AV
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Sympathomimetics)
RN  - 11128-99-7 (Angiotensin II)
RN  - HUQ1KC1YLI (Methoxamine)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Angiotensin II/*pharmacology
MH  - Animals
MH  - Blood Pressure
MH  - Electrophysiology
MH  - Epinephrine/pharmacology
MH  - Injections, Intravenous
MH  - Male
MH  - Medulla Oblongata/cytology/*physiology
MH  - Methoxamine/pharmacology
MH  - Neurons/*physiology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Sympathomimetics/pharmacology
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - 10.1152/ajpregu.1990.258.1.R70 [doi]
PST - ppublish
SO  - Am J Physiol. 1990 Jan;258(1 Pt 2):R70-6. doi: 10.1152/ajpregu.1990.258.1.R70.