PMID- 23016583
OWN - NLM
STAT- MEDLINE
DCOM- 20130910
LR  - 20130308
IS  - 1875-5305 (Electronic)
IS  - 0929-8665 (Linking)
VI  - 20
IP  - 4
DP  - 2013 Apr
TI  - Synergistic enhancement of cancer therapy using a combination of fusion protein 
      MG7-scFv/SEB and tumor necrosis factor alpha.
PG  - 467-72
AB  - The fusion protein MG7-scFv/SEB has shown anti-tumor activity on gastric cancer 
      in vitro and in vivo. Tumor necrosis factor-alpha (TNF-alpha) is a cytokine exerting 
      anti-tumor effectiveness in various models and modes of applications. In this 
      study, we explored the combination effects of MG7-scFv/SEB and TNF-alpha in 
      experimental gastric cancer. Both MG7-scFv/SEB and TNF-alpha could effectively result 
      in a significant inhibition of tumor growth in our experimental models when 
      administered alone. What's more, MG7-scFv/SEB synergized with TNF-alpha in further 
      reducing the growth of gastric tumors in gastric-tumor-bearing rats as compared 
      to mono therapy. Additionally, the survival rate of gastric-tumorbearing rats 
      administrated with combined therapy was significantly higher than that of rats 
      treated with MG7-scFv/SEB or TNF-alpha. These results indicate that combined therapy 
      with MG7-scFv/SEB and TNF-alpha is a promising strategy for human cancer therapy.
FAU - Lu, Xiaoming
AU  - Lu X
AD  - Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, 430022, China.
FAU - Cheng, Chao
AU  - Cheng C
FAU - Wang, Guobin
AU  - Wang G
FAU - Shu, Xiaogang
AU  - Shu X
FAU - Ma, Jingwei
AU  - Ma J
FAU - Tong, Qiang
AU  - Tong Q
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Protein Pept Lett
JT  - Protein and peptide letters
JID - 9441434
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Enterotoxins)
RN  - 0 (Immunoglobulin Fragments)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 39424-53-8 (enterotoxin B, staphylococcal)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/genetics
MH  - Antineoplastic Combined Chemotherapy Protocols/*pharmacology
MH  - Cell Line, Tumor
MH  - Drug Screening Assays, Antitumor
MH  - Enterotoxins/*genetics
MH  - Female
MH  - Humans
MH  - Immunoglobulin Fragments/genetics
MH  - Necrosis/chemically induced
MH  - Rats, Sprague-Dawley
MH  - Recombinant Fusion Proteins/administration & dosage/genetics/*pharmacology
MH  - Stomach Neoplasms/*drug therapy/mortality
MH  - Tumor Necrosis Factor-alpha/administration & dosage/*pharmacology
EDAT- 2012/09/29 06:00
MHDA- 2013/09/11 06:00
CRDT- 2012/09/29 06:00
PHST- 2010/06/30 00:00 [received]
PHST- 2010/10/21 00:00 [revised]
PHST- 2010/12/16 00:00 [accepted]
PHST- 2012/09/29 06:00 [entrez]
PHST- 2012/09/29 06:00 [pubmed]
PHST- 2013/09/11 06:00 [medline]
AID - PPL-EPUB-20120913-5 [pii]
PST - ppublish
SO  - Protein Pept Lett. 2013 Apr;20(4):467-72.