PMID- 23017014
OWN - NLM
STAT- MEDLINE
DCOM- 20130306
LR  - 20211021
IS  - 1471-4159 (Electronic)
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 124
IP  - 2
DP  - 2013 Jan
TI  - Role of TrkB expression in rat adrenal gland during acute immobilization stress.
PG  - 224-32
LID - 10.1111/jnc.12030 [doi]
AB  - Expression of tyrosine receptor kinase B (TrkB), a receptor for brain-derived 
      neurotrophic factor (BDNF), is markedly elevated in the adrenal medulla during 
      immobilization stress. Catecholamine release was confirmed in vitro by 
      stimulating chromaffin cells with recombinant BDNF. We investigated the role of 
      TrkB and the localization of BDNF in the adrenal gland during immobilization 
      stress for 60 min. Blood catecholamine levels increased after stimulation with 
      TrkB expressed in the adrenal medulla during 60-min stress; however, blood 
      catecholamine levels did not increase in adrenalectomized rats. Furthermore, 
      expression of BDNF mRNA and protein was detected in the adrenal medulla during 
      60-min stress. Similarly, in rats undergoing sympathetic nerve block with 
      propranolol, BDNF mRNA and protein were detected in the adrenal medulla during 
      60-min stress. These results suggest that signal transduction of TrkB in the 
      adrenal medulla evokes catecholamine release. In addition, catecholamine release 
      was evoked by both the hypothalamic-pituitary-adrenal axis and autocrine 
      signaling by BDNF in the adrenal gland. BDNF-TrkB interaction may play a role in 
      a positive feedback loop in the adrenal medulla during immobilization stress.
CI  - (c) 2012 The Authors Journal of Neurochemistry (c) 2012 International Society for 
      Neurochemistry.
FAU - Kondo, Yusuke
AU  - Kondo Y
AD  - Department of Environmental Pathology and Research Institute of Salivary Gland 
      and Health Medicine, Graduate School of Kanagawa Dental College, Yokosuka, Japan.
FAU - To, Masahiro
AU  - To M
FAU - Saruta, Juri
AU  - Saruta J
FAU - Hayashi, Takashi
AU  - Hayashi T
FAU - Sugiyama, Hiroki
AU  - Sugiyama H
FAU - Tsukinoki, Keiichi
AU  - Tsukinoki K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121025
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Acute Disease
MH  - Adrenal Medulla/metabolism/*physiopathology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/biosynthesis/*genetics
MH  - Gene Expression Regulation/physiology
MH  - Immobilization/adverse effects
MH  - Male
MH  - PC12 Cells
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/biosynthesis/*genetics
MH  - Stress, Psychological/*genetics/*metabolism/physiopathology
PMC - PMC3563005
EDAT- 2012/09/29 06:00
MHDA- 2013/03/07 06:00
CRDT- 2012/09/29 06:00
PHST- 2012/08/07 00:00 [received]
PHST- 2012/09/19 00:00 [revised]
PHST- 2012/09/19 00:00 [accepted]
PHST- 2012/09/29 06:00 [entrez]
PHST- 2012/09/29 06:00 [pubmed]
PHST- 2013/03/07 06:00 [medline]
AID - 10.1111/jnc.12030 [doi]
PST - ppublish
SO  - J Neurochem. 2013 Jan;124(2):224-32. doi: 10.1111/jnc.12030. Epub 2012 Oct 25.