PMID- 23017229
OWN - NLM
STAT- MEDLINE
DCOM- 20130513
LR  - 20211203
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Print)
IS  - 1043-4666 (Linking)
VI  - 60
IP  - 3
DP  - 2012 Dec
TI  - Genome-wide association replicates the association of Duffy antigen receptor for 
      chemokines (DARC) polymorphisms with serum monocyte chemoattractant protein-1 
      (MCP-1) levels in Hispanic children.
PG  - 634-8
LID - S1043-4666(12)00670-9 [pii]
LID - 10.1016/j.cyto.2012.08.029 [doi]
AB  - Obesity is associated with a chronic low inflammatory state characterized by 
      elevated levels of chemokines. Monocyte chemoattractant protein-1 (MCP-1) is a 
      member of the cysteine-cysteine (CC) chemokine family and is increased in 
      obesity. The purpose of this study was to identify loci regulating serum MCP-1 in 
      obese Hispanic children from the Viva La Familia Study. A genome-wide association 
      (GWA) analysis was performed in 815 children, ages 4-19 years, using genotypes 
      assayed with the Illumina HumanOmni1-Quad v1.0 BeadChips. All analyses were 
      performed in SOLAR using a linear regression-based test under an additive model 
      of allelic effect, while accounting for the relatedness of family members via a 
      kinship variance component. The strongest association for MCP-1 levels was found 
      with a non-synonymous single nucleotide polymorphism (SNP), rs12075, resulting in 
      an amino acid substitution (Asp42Gly) in the Duffy antigen receptor for 
      chemokines (DARC) gene product (minor allele frequency=43.6%, p=1.3 x 10(-21)) on 
      chromosome 1. Four other DARC SNPs were also significantly associated with MCP-1 
      levels (p<10(-16)-10(-6)). The Asp42Gly variant was associated with higher levels 
      of MCP-1 and accounted for approximately 10% of its variability. In addition, 
      MCP-1 levels were significantly associated with SNPs in chemokine receptor 3 
      (CCR3) and caspase recruitment domain family, member 9 (CARD9). In summary, the 
      association of the DARC Asp42Gly variant with MCP-1 levels replicates previous 
      GWA results substantiating a potential role for DARC in the regulation of 
      pro-inflammatory cytokines.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Voruganti, V Saroja
AU  - Voruganti VS
AD  - Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 
      78245-0549, USA. saroja@TxBiomedgenetics.org
FAU - Laston, Sandra
AU  - Laston S
FAU - Haack, Karin
AU  - Haack K
FAU - Mehta, Nitesh R
AU  - Mehta NR
FAU - Smith, C Wayne
AU  - Smith CW
FAU - Cole, Shelley A
AU  - Cole SA
FAU - Butte, Nancy F
AU  - Butte NF
FAU - Comuzzie, Anthony G
AU  - Comuzzie AG
LA  - eng
GR  - C06 RR013556/RR/NCRR NIH HHS/United States
GR  - C06 RR017515/RR/NCRR NIH HHS/United States
GR  - R01 DK080457/DK/NIDDK NIH HHS/United States
GR  - DK080457/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20120925
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (ACKR1 protein, human)
RN  - 0 (CARD Signaling Adaptor Proteins)
RN  - 0 (CARD9 protein, human)
RN  - 0 (CCL2 protein, human)
RN  - 0 (CCR3 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Duffy Blood-Group System)
RN  - 0 (Receptors, CCR3)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Adolescent
MH  - Amino Acid Substitution
MH  - CARD Signaling Adaptor Proteins/genetics
MH  - Chemokine CCL2/*blood/genetics
MH  - Child
MH  - Child, Preschool
MH  - Duffy Blood-Group System/*genetics
MH  - Female
MH  - Genome-Wide Association Study
MH  - Genotype
MH  - Hispanic or Latino/*genetics
MH  - Humans
MH  - Male
MH  - Obesity/blood/*genetics
MH  - Polymorphism, Single Nucleotide
MH  - Receptors, CCR3/genetics
MH  - Receptors, Cell Surface/*genetics
MH  - Young Adult
PMC - PMC3501981
MID - NIHMS410113
EDAT- 2012/09/29 06:00
MHDA- 2013/05/15 06:00
PMCR- 2013/12/01
CRDT- 2012/09/29 06:00
PHST- 2011/11/29 00:00 [received]
PHST- 2012/06/15 00:00 [revised]
PHST- 2012/08/29 00:00 [accepted]
PHST- 2012/09/29 06:00 [entrez]
PHST- 2012/09/29 06:00 [pubmed]
PHST- 2013/05/15 06:00 [medline]
PHST- 2013/12/01 00:00 [pmc-release]
AID - S1043-4666(12)00670-9 [pii]
AID - 10.1016/j.cyto.2012.08.029 [doi]
PST - ppublish
SO  - Cytokine. 2012 Dec;60(3):634-8. doi: 10.1016/j.cyto.2012.08.029. Epub 2012 Sep 
      25.