PMID- 23018907
OWN - NLM
STAT- MEDLINE
DCOM- 20140129
LR  - 20130603
IS  - 1399-3003 (Electronic)
IS  - 0903-1936 (Linking)
VI  - 41
IP  - 6
DP  - 2013 Jun
TI  - Obstructive sleep apnoea: longer respiratory event lengths in patients with heart 
      failure.
PG  - 1340-6
LID - 10.1183/09031936.00082212 [doi]
AB  - This study investigated the effect of heart failure on respiratory patterns in 
      patients with obstructive sleep apnoea (OSA). 39 patients with established OSA 
      (apnoea/hypopnoea index (AHI) >10 events.h(-1)) and either with heart failure 
      (New York Heart Association (NYHA) class II and III, left ventricular-ejection 
      fraction (LVEF) </=40%; n=26, age mean +/- SD 67 +/- 9 years) or without heart failure 
      (LVEF >/=50%, N-terminal pro-brain naturic peptide <400 pg.mL(-1); n=13, age 73 +/- 6 
      years) underwent simultaneous right- and left-heart catheterisation within 12 h 
      of cardiorespiratory polygraphy recording. Respiratory patterns of OSA were 
      significantly longer in OSA patients with heart failure versus without heart 
      failure, including mean +/- SD cycle length (46.0 +/- 10.0 versus 37.8 +/- 10.6 s; 
      p=0.024), ventilation length (25.4 +/- 6.3 versus 21.3 +/- 7.1 s; p=0.044), apnoea 
      length (20.5 +/- 4.9 versus 16.5 +/- 3.9 s; p=0.013), time-to-peak ventilation (10.6 
      +/- 3.0 versus 8.3 +/- 2.5 sc; p=0.021) and circulatory delay (28.5 +/- 7.5 versus 22.6 
      +/- 3.7 s; p=0.005). Positive and robust correlations were found between some of 
      these parameters and the degree of congestion in heart failure: cycle length 
      (r=0.53; p=0.006), ventilation length (r=0.55; p=0.004) and time-to-peak 
      ventilation (r=0.47; p=0.015) all increased with a rise in pulmonary capillary 
      wedge pressure. Respiratory patterns in OSA appear to be dependent on cardiac 
      function, with an increase in event lengths as cardiac function decreases. In 
      patients with heart failure, some of these events correlate with the degree of 
      pulmonary congestion.
FAU - Efken, Christina
AU  - Efken C
AD  - Dept of Cardiology, HDZ, Heart and Diabetes Centre North Rhine-Westphalia, Ruhr 
      University Bochum, Bad Oeynhausen, Germany.
FAU - Bitter, Thomas
AU  - Bitter T
FAU - Prib, Natalie
AU  - Prib N
FAU - Horstkotte, Dieter
AU  - Horstkotte D
FAU - Oldenburg, Olaf
AU  - Oldenburg O
LA  - eng
PT  - Journal Article
DEP - 20120927
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Aged
MH  - Cardiac Catheterization
MH  - Female
MH  - Heart Failure/*complications/physiopathology
MH  - Hemodynamics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/metabolism
MH  - Polysomnography
MH  - *Respiration
MH  - Risk Factors
MH  - Sex Factors
MH  - Sleep Apnea, Obstructive/*complications/*diagnosis/metabolism
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - Cardiac function
OT  - haemodynamics
OT  - respiratory patterns
OT  - sleep disordered breathing
EDAT- 2012/09/29 06:00
MHDA- 2014/01/30 06:00
CRDT- 2012/09/29 06:00
PHST- 2012/09/29 06:00 [entrez]
PHST- 2012/09/29 06:00 [pubmed]
PHST- 2014/01/30 06:00 [medline]
AID - 09031936.00082212 [pii]
AID - 10.1183/09031936.00082212 [doi]
PST - ppublish
SO  - Eur Respir J. 2013 Jun;41(6):1340-6. doi: 10.1183/09031936.00082212. Epub 2012 
      Sep 27.