PMID- 23019891
OWN - NLM
STAT- MEDLINE
DCOM- 20121106
LR  - 20121001
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 37
IP  - 13
DP  - 2012 Jul
TI  - [Meta-analysis on treatment of non-small cell lung cancer with brucea javanica 
      oil emulsion in combination with platinum-contained first-line chemotherapy].
PG  - 2022-9
AB  - OBJECTIVE: To study the efficacy and safety of brucea javanica oil emulsion 
      (BJOE) combining platinum-contained first-line chemotherapy in treating non small 
      cell lung cancer (NSCLC). METHOD: Cochrane library, PubMed, EMBASE, VIP, CBM and 
      CNKI were searched through computers. The search was finished in February, 2011. 
      Randomized controlled trials (RCTs) of BJOE combining platinum-contained 
      first-line chemotherapy were included. Two researchers extracted data and assess 
      literature quality separately,and made a meta-analyses by RevMan 5.1.2 software. 
      RESULT: Totally 22 RCTs involving 1512 patients were included. The Meta-analysis 
      showed that compared with the pure application of platinum-contained first-line 
      chemotherapy,the combination of BJOE and chemotherapy can enhance the near-term 
      curative effect (RR = 1. 31, 95% CI: 1.18-1.45, P < 0. 000 01), improve the 
      quality of life (RR = 1.78, 95% CI: 1.51-2. 09, P < 0.00001) and reduce the 
      suppression of bone marrow (OR = 0.37, 95% CI: 0. 27-0. 51, P < 0.00001) and the 
      gastrointestinal reactions (OR = 0.59, 95% CI: 0.44-0.80, P = 0.0007) ,with an 
      improvement in organism immunity. CONCLUSION: The current evidence indicates that 
      BJOE can enhance the chemotherapeutic effect on NSCLC patients, improve the 
      quality of life and reduce adverse effect of platinum-contained chemotherapeutics 
      and thus it is worth referring in clinic.
FAU - Wang, Quan
AU  - Wang Q
AD  - Evidence-Based Medicine Center of Lanzhou University, Lanzhou 730000, China. 
      wangquan2007@126.com
FAU - Wang, Mancai
AU  - Wang M
FAU - He, Xiran
AU  - He X
FAU - Gao, Tianming
AU  - Gao T
FAU - Cao, Hui
AU  - Cao H
FAU - Dou, Wenjie
AU  - Dou W
FAU - Tian, Jinhui
AU  - Tian J
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Meta-Analysis
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Emulsions)
RN  - 0 (Organoplatinum Compounds)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
MH  - Brucea/*chemistry
MH  - Carcinoma, Non-Small-Cell Lung/*drug therapy
MH  - Drugs, Chinese Herbal/administration & dosage
MH  - Emulsions/administration & dosage
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*drug therapy
MH  - Male
MH  - Middle Aged
MH  - Organoplatinum Compounds/administration & dosage
MH  - Phytotherapy
MH  - Randomized Controlled Trials as Topic
MH  - Young Adult
EDAT- 2012/10/02 06:00
MHDA- 2012/11/07 06:00
CRDT- 2012/10/02 06:00
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2012/11/07 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2012 Jul;37(13):2022-9.