PMID- 23020308
OWN - NLM
STAT- MEDLINE
DCOM- 20130429
LR  - 20221207
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 80
IP  - 5
DP  - 2012 Nov
TI  - The HLA-B gene and Hashimoto disease in Han Chinese children: a case-control and 
      family-based study.
PG  - 431-6
LID - 10.1111/tan.12003 [doi]
AB  - Hashimoto disease (HD) is an autoimmune thyroid disease resulting from complex 
      interactions between genetic and environmental factors. The human leukocyte 
      antigen (HLA) gene has been established to be involved in the susceptibility to 
      HD. We aim to investigate the associations between HLA-B alleles and Han Chinese 
      children with HD by both case-control and family-based studies. A total of 108 
      unrelated children with HD, 380 unrelated healthy controls, 58 trios of affected 
      patients and their parents, and 75 trios of unaffected siblings and their parents 
      were recruited. HLA-B genotyping was performed by polymerase chain reaction and 
      detected with a sequence-specific oligonucleotide probes system. We found that 
      B*46:01 allele (OR = 2.31, 95% CI 1.60-3.34, P(c) = 9.99 x 10(-5)) and carrier 
      (OR = 3.28, 95% CI 2.10-5.11, P(c) = 1.35 x 10(-6)) were associated with HD risk. 
      Transmission/disequilibrium test further confirmed an overtransmission of the 
      B*46:01 (OR 2.55, 95% CI 1.36-6.10, P = 6.5 x 10(-3)). The findings were similar 
      in females when stratified by gender. In conclusion, our results clearly identify 
      that HLA-B*46:01 confers susceptibility to HD in Han Chinese children. Further 
      studies with larger children cohort are required to confirm the role of B*46:01 
      in the development of HD.
CI  - (c) 2012 John Wiley & Sons A/S.
FAU - Huang, C-Y
AU  - Huang CY
AD  - Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.
FAU - Chang, T-Y
AU  - Chang TY
FAU - Chu, C-C
AU  - Chu CC
FAU - Lo, F-S
AU  - Lo FS
FAU - Ting, W-H
AU  - Ting WH
FAU - Lin, C-H
AU  - Lin CH
FAU - Wu, Y-L
AU  - Wu YL
FAU - Chu, S-Y
AU  - Chu SY
FAU - Chang, S-C
AU  - Chang SC
FAU - Chen, W-F
AU  - Chen WF
FAU - Lin, C-L
AU  - Lin CL
FAU - Lin, W-S
AU  - Lin WS
FAU - Lee, Y-J
AU  - Lee YJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B*46:01 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - *Asian People
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Family
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - HLA-B Antigens/*genetics/immunology
MH  - Haplotypes
MH  - Hashimoto Disease/*genetics/immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Siblings
EDAT- 2012/10/02 06:00
MHDA- 2013/04/30 06:00
CRDT- 2012/10/02 06:00
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2013/04/30 06:00 [medline]
AID - 10.1111/tan.12003 [doi]
PST - ppublish
SO  - Tissue Antigens. 2012 Nov;80(5):431-6. doi: 10.1111/tan.12003.