PMID- 23020309
OWN - NLM
STAT- MEDLINE
DCOM- 20130429
LR  - 20221207
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 80
IP  - 5
DP  - 2012 Nov
TI  - Distinct HLA allele and haplotype distributions in four ethnic groups of China.
PG  - 452-61
LID - 10.1111/tan.12007 [doi]
AB  - Distinct human leukocyte antigen (HLA) allele and haplotype distributions occur 
      in the northern and southern Han populations of China. However, different ethnic 
      groups in China show limited regional distributions for many HLA alleles and 
      haplotypes. Therefore, it is necessary and meaningful to study the differences in 
      HLA allele and haplotype distribution for northern and southern ethnic groups of 
      China. A total of 428 unrelated individuals from the Lisu, Nu, Tu and Yugur 
      ethnic populations were genotyped for HLA-A, -B, -C and -DRB1 alleles using the 
      PCR-Luminex typing method. The frequencies of HLA alleles and statistically 
      inferred haplotypes were calculated. A total of 29 HLA-A, 54 HLA-B, 27 HLA-C and 
      41 HLA-DRB1 alleles were spread throughout these four populations with distinct 
      allele and deduced haplotype frequencies between populations. Some alleles and 
      deduced haplotypes exhibited significantly different distributions between 
      northern (Tu and Yugur) and southern groups (Lisu and Nu). A phylogenetic tree 
      and principal component analysis were used to compare the HLA polymorphism 
      between our dataset and 19 other eastern and southeastern Asian populations. This 
      analysis showed that Lisu and Nu belong to a cluster of southern ethnic groups, 
      while Tu and Yugur are most closely related to other northern groups. Thus, 
      distinct ethnic population histories were revealed by analyzing HLA allelic 
      polymorphisms with the HLA profiles of the Lisu and Nu southern Chinese ethnic 
      groups clearly different from the Tu and Yugur northern ethnic groups. The 
      results will be useful for future association studies of infectious disease and 
      contribute toward a more efficient search of organ/tissue matches for 
      transplantation.
CI  - (c) 2012 John Wiley & Sons A/S.
FAU - Yao, Y
AU  - Yao Y
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, Kunming, 650118, China.
FAU - Shi, L
AU  - Shi L
FAU - Tao, Y
AU  - Tao Y
FAU - Kulski, J K
AU  - Kulski JK
FAU - Lin, K
AU  - Lin K
FAU - Huang, X
AU  - Huang X
FAU - Xiang, H
AU  - Xiang H
FAU - Chu, J
AU  - Chu J
FAU - Shi, L
AU  - Shi L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
SB  - IM
MH  - *Alleles
MH  - Asian People
MH  - China
MH  - *Gene Frequency
MH  - Genotype
MH  - HLA Antigens/classification/*genetics/immunology
MH  - Haplotypes
MH  - Histocompatibility Testing
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Phylogeny
MH  - Phylogeography
MH  - *Polymorphism, Genetic
MH  - Principal Component Analysis
EDAT- 2012/10/02 06:00
MHDA- 2013/04/30 06:00
CRDT- 2012/10/02 06:00
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2013/04/30 06:00 [medline]
AID - 10.1111/tan.12007 [doi]
PST - ppublish
SO  - Tissue Antigens. 2012 Nov;80(5):452-61. doi: 10.1111/tan.12007.