PMID- 23020784
OWN - NLM
STAT- MEDLINE
DCOM- 20130424
LR  - 20140731
IS  - 1362-3095 (Electronic)
IS  - 0955-3002 (Linking)
VI  - 89
IP  - 3
DP  - 2013 Mar
TI  - Altered brain metabolism after whole body irradiation in mice: a preliminary in 
      vivo 1H MRS study.
PG  - 212-8
LID - 10.3109/09553002.2013.734944 [doi]
AB  - Abstract Purpose: In the classical description of acute radiation syndrome, the 
      role of central nervous system (CNS) is underestimated. It is now well recognised 
      that ionising radiation-induced oxidative stress may bring about functional 
      changes in the brain. In this study, we prospectively evaluated metabolic changes 
      in the brain after whole body irradiation in mice using in vivo proton ((1)H) 
      nuclear magnetic resonance spectroscopy (MRS). MATERIAL AND METHODS: Young adult 
      mice were exposed to whole body irradiation of 8 Gy and controls were sham 
      irradiated. In vivo (1)H MRS from cortex-hippocampus and hypothalamic-thalamic 
      region of brain at different time points, i.e., as early as 6 hours, day 1, 2, 3, 
      5 and 10 post irradiation was carried out at 7 Tesla animal magnetic resonance 
      imaging system. Brain metabolites were measured and quantitative analysis of 
      detectable metabolites was performed by linear combination of model (LCModel). 
      RESULTS: Significant reduction in myoinositol (p = 0.03) and taurine (p = 0.02) 
      ratios were observed in cortex-hippocampus region as early as day 2 post 
      irradiation compared to controls. These metabolic alterations remained sustained 
      over day 10 post irradiation. CONCLUSIONS: The results of this preliminary study 
      suggest that the alteration/reduction in the mI and Tau concentration may be 
      associated with physiological perturbations in astrocytes or radiation induced 
      neuro-inflammatory response triggered in microglial cell.
FAU - Rana, Poonam
AU  - Rana P
AD  - NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences (INMAS), 
      Delhi.
FAU - Khan, Ahmad Raza
AU  - Khan AR
FAU - Modi, Shilpi
AU  - Modi S
FAU - Hemanth Kumar, B S
AU  - Hemanth Kumar BS
FAU - Javed, Salim
AU  - Javed S
FAU - Tripathi, Rajendra Prasad
AU  - Tripathi RP
FAU - Khushu, Subash
AU  - Khushu S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121108
PL  - England
TA  - Int J Radiat Biol
JT  - International journal of radiation biology
JID - 8809243
RN  - 020IUV4N33 (Phosphocreatine)
RN  - 0RH81L854J (Glutamine)
RN  - 1EQV5MLY3D (Taurine)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 4L6452S749 (Inositol)
RN  - 997-55-7 (N-acetylaspartate)
RN  - MU72812GK0 (Creatine)
RN  - N91BDP6H0X (Choline)
SB  - IM
MH  - Animals
MH  - Aspartic Acid/analogs & derivatives/metabolism
MH  - Brain/*metabolism/*radiation effects
MH  - Cerebral Cortex/metabolism/radiation effects
MH  - Choline/metabolism
MH  - Creatine/metabolism
MH  - Glutamic Acid/metabolism
MH  - Glutamine/metabolism
MH  - Hippocampus/metabolism/radiation effects
MH  - Hypothalamus/metabolism/radiation effects
MH  - Inositol/metabolism
MH  - Magnetic Resonance Spectroscopy
MH  - Male
MH  - Mice
MH  - Models, Neurological
MH  - Oxidative Stress/radiation effects
MH  - Phosphocreatine/metabolism
MH  - Taurine/metabolism
MH  - Thalamus/metabolism/radiation effects
MH  - Time Factors
MH  - Tissue Distribution
EDAT- 2012/10/02 06:00
MHDA- 2013/04/25 06:00
CRDT- 2012/10/02 06:00
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2013/04/25 06:00 [medline]
AID - 10.3109/09553002.2013.734944 [doi]
PST - ppublish
SO  - Int J Radiat Biol. 2013 Mar;89(3):212-8. doi: 10.3109/09553002.2013.734944. Epub 
      2012 Nov 8.