PMID- 23020799
OWN - NLM
STAT- MEDLINE
DCOM- 20130910
LR  - 20220321
IS  - 1365-2982 (Electronic)
IS  - 1350-1925 (Linking)
VI  - 25
IP  - 2
DP  - 2013 Feb
TI  - The val66met polymorphism of brain-derived neurotrophic factor is associated with 
      human esophageal hypersensitivity.
PG  - 162-e85
LID - 10.1111/nmo.12021 [doi]
AB  - BACKGROUND: Recent evidence implicates brain-derived neurotrophic factor (BDNF) 
      in visceral hypersensitivity and pain in functional gastrointestinal disorders. 
      We hypothesized that presence of the val66met polymorphism in the BDNF gene would 
      be linked to increased esophageal sensitivity to electrical stimulation. METHODS: 
      A total of 39 healthy volunteers (20 males, mean age 30) compliant with inclusion 
      criteria after screening procedures were genotyped for BDNF polymorphisms and 
      completed an Hospital Anxiety and Depression Scale (HADS) questionnaire. Sensory 
      (ST) and pain (PT) thresholds in the proximal (PE) and distal (DE) esophagus were 
      determined using electrical stimuli to a swallowed intraluminal catheter with 
      bipolar electrodes by an investigator blinded to the subjects' genotype. For 
      comparison, somatic ST and PT (hand and foot) were also tested. HADS scores 
      together with esophageal and somatic thresholds were then correlated with BDNF 
      polymorphism status. KEY RESULTS: Eleven of 39 (28%) volunteers had at least one 
      Met allele (Met carriers). When compared with Val/Val, Met carriers had lower 
      esophageal PT (Median PT [mA]: Val/Val vs Met carriers, PE; 49.4 vs 44.3, P = 
      0.033, DE: 63.8 vs 55.4, P = 0.045) with higher proportion of Val/Val subjects in 
      the upper quartile for PT in both PE (P = 0.021) and DE (P = 0.033), yet similar 
      somatic PT (Median PT [mA] Hand; 33.6 vs 38.0, P = 0.22, Foot; 44.7 vs 44.0, P = 
      0.48). Sensitivity results were independent of anxiety (P = 0.66) and depression 
      (P = 0.33) scores. CONCLUSIONS & INFERENCES: val66met BDNF polymorphisms are 
      associated with increased esophageal sensitivity to experimental electrical 
      stimulation. Thus, BDNF genotype may be a useful biomarker for electrical 
      sensitivity in the healthy human esophagus.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Vasant, D H
AU  - Vasant DH
AD  - Gastrointestinal Centre, Institute of Inflammation and Repair, Faculty of Medical 
      and Human Sciences, University of Manchester, Salford Royal NHS Foundation Trust, 
      Salford, UK.
FAU - Payton, A
AU  - Payton A
FAU - Mistry, S
AU  - Mistry S
FAU - Thompson, D G
AU  - Thompson DG
FAU - Hamdy, S
AU  - Hamdy S
LA  - eng
PT  - Journal Article
DEP - 20121001
PL  - England
TA  - Neurogastroenterol Motil
JT  - Neurogastroenterology and motility
JID - 9432572
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Anxiety Disorders/genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Electric Stimulation
MH  - Esophagus/*physiology
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Humans
MH  - Male
MH  - *Polymorphism, Single Nucleotide
MH  - Sensory Thresholds/*physiology
EDAT- 2012/10/02 06:00
MHDA- 2013/09/11 06:00
CRDT- 2012/10/02 06:00
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2013/09/11 06:00 [medline]
AID - 10.1111/nmo.12021 [doi]
PST - ppublish
SO  - Neurogastroenterol Motil. 2013 Feb;25(2):162-e85. doi: 10.1111/nmo.12021. Epub 
      2012 Oct 1.