PMID- 23020971
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20211021
IS  - 1471-5007 (Electronic)
IS  - 1471-4922 (Print)
IS  - 1471-4922 (Linking)
VI  - 28
IP  - 11
DP  - 2012 Nov
TI  - PfCRT and its role in antimalarial drug resistance.
PG  - 504-14
LID - S1471-4922(12)00142-0 [pii]
LID - 10.1016/j.pt.2012.08.002 [doi]
AB  - Plasmodium falciparum resistance to chloroquine, the former gold standard 
      antimalarial drug, is mediated primarily by mutant forms of the chloroquine 
      resistance transporter (PfCRT). These mutations impart upon PfCRT the ability to 
      efflux chloroquine from the intracellular digestive vacuole, the site of drug 
      action. Recent studies reveal that PfCRT variants can also affect parasite 
      fitness, protect immature gametocytes against chloroquine action, and alter P. 
      falciparum susceptibility to current first-line therapies. These results 
      highlight the need to be vigilant in screening for the appearance of novel pfcrt 
      alleles that could contribute to new multi-drug resistance phenotypes.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Ecker, Andrea
AU  - Ecker A
AD  - Department of Microbiology and Immunology, College of Physicians and Surgeons, 
      Columbia University, New York, NY 10032, USA.
FAU - Lehane, Adele M
AU  - Lehane AM
FAU - Clain, Jerome
AU  - Clain J
FAU - Fidock, David A
AU  - Fidock DA
LA  - eng
GR  - R01 AI050234/AI/NIAID NIH HHS/United States
GR  - R37 AI050234/AI/NIAID NIH HHS/United States
GR  - R01 AI50234/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120925
PL  - England
TA  - Trends Parasitol
JT  - Trends in parasitology
JID - 100966034
RN  - 0 (Antimalarials)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (PfCRT protein, Plasmodium falciparum)
RN  - 0 (Protozoan Proteins)
SB  - IM
MH  - Antimalarials/pharmacology/therapeutic use
MH  - Drug Resistance/*genetics
MH  - Humans
MH  - Malaria, Falciparum/drug therapy/parasitology
MH  - Membrane Transport Proteins/*genetics/*metabolism
MH  - Mutation
MH  - Plasmodium falciparum/drug effects/*genetics/*metabolism
MH  - Protozoan Proteins/*genetics/*metabolism
PMC - PMC3478492
MID - NIHMS401880
EDAT- 2012/10/02 06:00
MHDA- 2013/01/19 06:00
PMCR- 2013/11/01
CRDT- 2012/10/02 06:00
PHST- 2012/07/18 00:00 [received]
PHST- 2012/08/09 00:00 [revised]
PHST- 2012/08/13 00:00 [accepted]
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
PHST- 2013/11/01 00:00 [pmc-release]
AID - S1471-4922(12)00142-0 [pii]
AID - 10.1016/j.pt.2012.08.002 [doi]
PST - ppublish
SO  - Trends Parasitol. 2012 Nov;28(11):504-14. doi: 10.1016/j.pt.2012.08.002. Epub 
      2012 Sep 25.